INSPIRE Trial for Abdominal Infections

Last updated: May 28, 2024
Sponsor: Harvard Pilgrim Health Care
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

N/A

Treatment

Arm 1: Routine Care

Arm 2: INSPIRE Stewardship Bundle for Abdominal Infection

Clinical Study ID

NCT05423743
PH000763B_ABD
  • Ages > 18
  • All Genders

Study Summary

The INSPIRE Abdominal Infection Trial is a cluster-randomized controlled trial of HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with real-time, precision medicine computerized physician order entry (CPOE) smart prompts providing the probability that a non-critically ill adult admitted with abdominal infection is infected with a resistant pathogen.

Note: enrolled "subjects" represent 102 individual HCA Healthcare hospitals that have been randomized into 92 clusters. Hospitals were grouped into the same randomization cluster if they shared campuses or antibiotic stewardship staff.

Eligibility Criteria

Inclusion

Facility Inclusion Criteria:

  1. HCA Healthcare hospitals admitting adults for abdominal infection

  2. Facility use of MEDITECH as their electronic health record system

Exclusion

Facility Exclusion Criteria:

  • Note: unit of randomization is the hospital, however the computerized physician order entry (CPOE) alert intervention will calculate risk estimates for adults age >=18 admitted to non-intensive care unit wards and who are ordered to receive extended-spectrum antibiotics for abdominal infection.

Study Design

Total Participants: 102
Treatment Group(s): 2
Primary Treatment: Arm 1: Routine Care
Phase:
Study Start date:
January 01, 2023
Estimated Completion Date:
December 31, 2028

Connect with a study center

  • Riverside Community Hospital

    Riverside, California 92501
    United States

    Site Not Available

  • Good Samaritan Hospital

    San Jose, California 95124
    United States

    Site Not Available

  • Regional Medical Center of San Jose

    San Jose, California 95116
    United States

    Site Not Available

  • Los Robles Hospital & Medical Center

    Thousand Oaks, California 91362
    United States

    Site Not Available

  • West Hills Hospital & Medical Center

    West Hills, California 91307
    United States

    Site Not Available

  • The Medical Center of Aurora

    Aurora, Colorado 80012
    United States

    Site Not Available

  • Swedish Medical Center

    Englewood, Colorado 80113
    United States

    Site Not Available

  • Sky Ridge Medical Center

    Lone Tree, Colorado 80124
    United States

    Site Not Available

  • North Suburban Medical Center

    Thornton, Colorado 80229
    United States

    Site Not Available

  • Blake Medical Center

    Bradenton, Florida 34209
    United States

    Site Not Available

  • Brandon Regional Hospital

    Brandon, Florida 33511
    United States

    Site Not Available

  • Oak Hill Hospital

    Brooksville, Florida 34613
    United States

    Site Not Available

  • Englewood Community Hospital

    Englewood, Florida 34223
    United States

    Site Not Available

  • Lawnwood Regional Medical Center

    Fort Pierce, Florida 34950
    United States

    Site Not Available

  • Fort Walton Beach Medical Center

    Fort Walton Beach, Florida 32547
    United States

    Site Not Available

  • Regional Medical Center of Bayonet Point

    Hudson, Florida 34667
    United States

    Site Not Available

  • Memorial Hospital Jacksonville

    Jacksonville, Florida 32216
    United States

    Site Not Available

  • Lake City Medical Center

    Lake City, Florida 32055
    United States

    Site Not Available

  • Largo Medical Center

    Largo, Florida 33770
    United States

    Site Not Available

  • Northwest Medical Center

    Margate, Florida 33063
    United States

    Site Not Available

  • Kendall Regional Medical Center

    Miami, Florida 33175
    United States

    Site Not Available

  • Mercy Hospital

    Miami, Florida 33133
    United States

    Site Not Available

  • Orange Park Medical Center

    Orange Park, Florida 32073
    United States

    Site Not Available

  • Oviedo Medical Center

    Oviedo, Florida 32765
    United States

    Site Not Available

  • Gulf Coast Regional Medical Center

    Panama City, Florida 32405
    United States

    Site Not Available

  • Fawcett Memorial Hospital

    Port Charlotte, Florida 33952
    United States

    Site Not Available

  • St. Lucie Medical Center

    Port Saint Lucie, Florida 34952
    United States

    Site Not Available

  • Northside Hospital

    Saint Petersburg, Florida 33709
    United States

    Site Not Available

  • Palms of Pasadena

    Saint Petersburg, Florida 33707
    United States

    Site Not Available

  • St. Petersburg General Hospital

    Saint Petersburg, Florida 33710
    United States

    Site Not Available

  • Doctors Hospital of Sarasota

    Sarasota, Florida 34233
    United States

    Site Not Available

  • South Bay Hospital

    Sun City Center, Florida 33573
    United States

    Site Not Available

  • Capital Regional Medical Center

    Tallahassee, Florida 32308
    United States

    Site Not Available

  • HCA Florida South Tampa Hospital

    Tampa, Florida 33609
    United States

    Site Not Available

  • HCA Florida West Tampa Hospital

    Tampa, Florida 33615
    United States

    Site Not Available

  • Medical Center of Trinity

    Trinity, Florida 34655
    United States

    Site Not Available

  • JFK Medical Center - North Campus

    West Palm Beach, Florida 33407
    United States

    Site Not Available

  • Fairview Park Hospital

    Dublin, Georgia 31040
    United States

    Site Not Available

  • Eastern Idaho Regional Medical Center

    Idaho Falls, Idaho 83404
    United States

    Site Not Available

  • Menorah Medical Center

    Overland Park, Kansas 66209
    United States

    Site Not Available

  • Overland Park Regional Medical Center

    Overland Park, Kansas 66215
    United States

    Site Not Available

  • Wesley Medical Center

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Wesley Woodlawn Hospital & ER

    Wichita, Kansas 67220
    United States

    Site Not Available

  • TriStar Greenview Regional Hospital

    Bowling Green, Kentucky 41204
    United States

    Site Not Available

  • Lakeview Regional Medical Center

    Covington, Louisiana 70433
    United States

    Site Not Available

  • Tulane Medical Center

    New Orleans, Louisiana 70112
    United States

    Site Not Available

  • Centerpoint Medical Center

    Independence, Missouri 64057
    United States

    Site Not Available

  • Research Medical Center

    Kansas City, Missouri 64132
    United States

    Site Not Available

  • Lee's Summit Medical Center

    Lee's Summit, Missouri 64063
    United States

    Site Not Available

  • Southern Hills Hospital & Medical Center

    Las Vegas, Nevada 89109
    United States

    Site Not Available

  • Sunrise Hospital & Medical Center

    Las Vegas, Nevada 89109
    United States

    Site Not Available

  • Trident Medical Center

    Charleston, South Carolina 29406
    United States

    Site Not Available

  • Grand Strand Medical Center

    Myrtle Beach, South Carolina 29572
    United States

    Site Not Available

  • Parkridge East Hospital

    Chattanooga, Tennessee 37412
    United States

    Site Not Available

  • Parkridge Medical Center

    Chattanooga, Tennessee 37404
    United States

    Site Not Available

  • TriStar Horizon Medical Center

    Dickson, Tennessee 37055
    United States

    Site Not Available

  • TriStar Hendersonville Medical Center

    Hendersonville, Tennessee 37075
    United States

    Site Not Available

  • TriStar Centennial Medical Center

    Nashville, Tennessee 37203
    United States

    Site Not Available

  • TriStar Southern Hills Medical Center

    Nashville, Tennessee 37211
    United States

    Site Not Available

  • TriStar StoneCrest Medical Center

    Smyrna, Tennessee 37167
    United States

    Site Not Available

  • Medical City Arlington

    Arlington, Texas 76015
    United States

    Site Not Available

  • St. David's Medical Center

    Austin, Texas 78705
    United States

    Site Not Available

  • St. David's North Austin Medical Center

    Austin, Texas 78758
    United States

    Site Not Available

  • Valley Regional Medical Center

    Brownsville, Texas 78526
    United States

    Site Not Available

  • HCA Houston Healthcare Conroe

    Conroe, Texas 77304
    United States

    Site Not Available

  • Corpus Christi Medical Center - Bay Area

    Corpus Christi, Texas 78412
    United States

    Site Not Available

  • Corpus Christi Medical Center - Doctors Regional

    Corpus Christi, Texas 78412
    United States

    Site Not Available

  • Corpus Christi Medical Center - Heart Hospital

    Corpus Christi, Texas 78412
    United States

    Site Not Available

  • Medical City Dallas

    Dallas, Texas 75230
    United States

    Site Not Available

  • Medical City Denton

    Denton, Texas 76210
    United States

    Site Not Available

  • Del Sol Medical Center

    El Paso, Texas 79925
    United States

    Site Not Available

  • Las Palmas Medical Center

    El Paso, Texas 79902
    United States

    Site Not Available

  • Medical City Alliance

    Fort Worth, Texas 76177
    United States

    Site Not Available

  • Medical City Fort Worth

    Fort Worth, Texas 76104
    United States

    Site Not Available

  • Medical City Frisco

    Frisco, Texas 75034
    United States

    Site Not Available

  • HCA Houston Healthcare West

    Houston, Texas 77082
    United States

    Site Not Available

  • Medical City Las Colinas

    Irving, Texas 75039
    United States

    Site Not Available

  • HCA Houston Healthcare Kingwood

    Kingwood, Texas 77339
    United States

    Site Not Available

  • Medical City Lewisville

    Lewisville, Texas 75057
    United States

    Site Not Available

  • Methodist Hospital Northeast

    Live Oak, Texas 78233
    United States

    Site Not Available

  • Rio Grande Regional Hospital Main Campus

    McAllen, Texas 78503
    United States

    Site Not Available

  • Medical City McKinney

    McKinney, Texas 75069
    United States

    Site Not Available

  • Medical City North Hills

    North Richland Hills, Texas 76180
    United States

    Site Not Available

  • HCA Houston Healthcare Southeast

    Pasadena, Texas 77504
    United States

    Site Not Available

  • HCA Houston Healthcare Pearland

    Pearland, Texas 77584
    United States

    Site Not Available

  • Medical City Plano

    Plano, Texas 75075
    United States

    Site Not Available

  • St. David's Round Rock Medical Center

    Round Rock, Texas 78681
    United States

    Site Not Available

  • Methodist Hospital

    San Antonio, Texas 78229
    United States

    Site Not Available

  • Methodist Hospital Metropolitan

    San Antonio, Texas 78212
    United States

    Site Not Available

  • Methodist Hospital Texsan

    San Antonio, Texas 78201
    United States

    Site Not Available

  • Methodist Hospital | Specialty and Transplant

    San Antonio, Texas 78229
    United States

    Site Not Available

  • HCA Houston Healthcare Mainland

    Texas City, Texas 77591
    United States

    Site Not Available

  • Medical City Weatherford

    Weatherford, Texas 76086
    United States

    Site Not Available

  • HCA Houston Healthcare Clear Lake

    Webster, Texas 77598
    United States

    Site Not Available

  • Ogden Regional Medical Center

    Ogden, Utah 84405
    United States

    Site Not Available

  • LewisGale Hospital Montgomery

    Blacksburg, Virginia 24060
    United States

    Site Not Available

  • LewisGale Hospital Pulaski

    Pulaski, Virginia 24301
    United States

    Site Not Available

  • Reston Hospital Center

    Reston, Virginia 20190
    United States

    Site Not Available

  • CJW Medical Center (Chippenham & Johnston Willis Campuses)

    Richmond, Virginia 23225
    United States

    Site Not Available

  • Henrico Doctors' Hospital

    Richmond, Virginia 23229
    United States

    Site Not Available

  • LewisGale Medical Center

    Salem, Virginia 24153
    United States

    Site Not Available

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