Phase
Condition
Cystic Fibrosis
Lung Disease
Scar Tissue
Treatment
VX-121/TEZ/D-IVA
Clinical Study ID
Study Summary
Eligibility Criteria
Inclusion
Key Inclusion Criteria:
- Participants with stable CF and at least 1 TCR mutation (including F508del) in theCFTR gene
Exclusion
Key Exclusion Criteria:
History of solid organ, hematological transplantation, or cancer
Hepatic cirrhosis with portal hypertension, moderate hepatic impairment (Child PughScore 7 to 9), or severe hepatic impairment (Child Pugh Score 10 to 15)
Lung infection with organisms associated with a more rapid decline in pulmonarystatus
Other protocol defined Inclusion/Exclusion criteria may apply.
Study Design
Connect with a study center
Telethon Kids Institute
Nedlands,
AustraliaSite Not Available
The Kids Research Institute Australia
Nedlands,
AustraliaSite Not Available
Women & Children's Hospital
North Adelaide,
AustraliaSite Not Available
Women's and Children's Hospital
North Adelaide,
AustraliaSite Not Available
The Royal Children's Hospital
Parkville,
AustraliaSite Not Available
Queensland Children's Hospital
South Brisbane,
AustraliaSite Not Available
The Hospital for Sick Children
Toronto,
CanadaSite Not Available
British Columbia Children's Hospital
Vancouver,
CanadaSite Not Available
CHU Lyon - Hopital Femme Mere-Enfant
Bron,
FranceSite Not Available
CHU Lyon - Hopital Femme Mere-Enfant
Bron Cedex,
FranceActive - Recruiting
Hopital Necker, Enfants Malades
Paris,
FranceSite Not Available
Hopital Necker, Enfants Malades
Paris Cedex 15,
FranceActive - Recruiting
Charite Paediatric Pulmonology Department
Berlin,
GermanySite Not Available
Charité - Paediatric Pulmonology Department
Berlin,
GermanySite Not Available
Kinderklinik III, Abt. fur Pneumologie
Essen,
GermanyActive - Recruiting
Universitatsklinikum Essen
Essen,
GermanySite Not Available
Medizinische Hochschule Hannover
Hannover,
GermanyActive - Recruiting
Medizinische Hochschule Hannover
Hanover,
GermanySite Not Available
Erasmus Medical Center / Sophia Children's Hospital
Rotterdam,
NetherlandsSite Not Available
Starship Children's Hospital
Grafton,
New ZealandSite Not Available
Sahlgrenska Universitetssjukhuset
Gothenburg,
SwedenSite Not Available
Sahlgrenska Universitetssjukhuset
Göteborg,
SwedenActive - Recruiting
Karolinska University Hospital - Pulmonology
Stockholm,
SwedenSite Not Available
Inselspital - Universitaetsspital Bern
Bern,
SwitzerlandSite Not Available
Kinderspital Zurich
Zurich,
SwitzerlandSite Not Available
Kinderspital Zuerich
Zürich,
SwitzerlandActive - Recruiting
Children and Young Adults Research Unit
Cardiff,
United KingdomSite Not Available
Great Ormond Street Hospital for Children
London,
United KingdomSite Not Available
Children's Hospital of Orange County
Orange, California 92868
United StatesSite Not Available
Stanford University
Palo Alto, California 94304
United StatesSite Not Available
Stanford University Clinical and Translational Research Unit
Palo Alto, California 94304
United StatesSite Not Available
Children's Hospital of Colorado
Aurora, Colorado 80045
United StatesSite Not Available
The Emory Clinic / Children's Healthcare of Atlanta at Egleston
Atlanta, Georgia 30322
United StatesSite Not Available
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois 60611
United StatesSite Not Available
Riley Hospital for Children at Indiana University Health
Indianapolis, Indiana 46202
United StatesSite Not Available
Boston Children's Hospital
Boston, Massachusetts 02115
United StatesSite Not Available
Children's Respiratory and Critical Care Specialists, P.A., Children's Hospitals and Clinics of Minnesota
Minneapolis, Minnesota 55404
United StatesSite Not Available
The Children's Mercy Hospital
Kansas City, Missouri 64108
United StatesSite Not Available
Washington University School of Medicine / St. Louis Children's Hospital
Saint Louis, Missouri 63110
United StatesActive - Recruiting
Washington University School of Medicine / St. Louis Children's Hospital
St Louis, Missouri 63110
United StatesSite Not Available
Cohen Children's Medical Center
Lake Success, New York 11042
United StatesSite Not Available
Cohen Children's Medical Center
New York, New York 11042
United StatesActive - Recruiting
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio 45229
United StatesSite Not Available
Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center
Cleveland, Ohio 44106
United StatesSite Not Available
Nationwide Children's Hospital
Columbus, Ohio 43205
United StatesSite Not Available
Oregon Health & Science University
Portland, Oregon 97239
United StatesSite Not Available
UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania 15224
United StatesSite Not Available
Texas Children's Hospital - Baylor College of Medicine
Houston, Texas 77030
United StatesSite Not Available
Texas Children's Hospital - Wallace Tower
Houston, Texas 77030
United StatesSite Not Available
Vermont Lung Center
Colchester, Vermont 05446
United StatesSite Not Available
American Family Childrens Hospital
Madison, Wisconsin 53792
United StatesSite Not Available
University of Wisconsin Hospital and Clinics
Madison, Wisconsin 53792
United StatesSite Not Available
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