A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma

Last updated: March 12, 2026
Sponsor: Janssen Research & Development, LLC
Overall Status: Active - Recruiting

Phase

1/2

Condition

Lymphoma

Lymphoma, B-cell

Treatment

Prizloncabtagene autoleucel (Prizlo-Cel)

JNJ-90014496

Clinical Study ID

NCT05421663
90014496LYM1001
2023-506267-33
90014496LYM1001
2023-506267-33-00
  • Ages > 18
  • All Genders

Study Summary

This is a Phase 1b/2, multicenter, open-label, study of prizloncabtagene autoleucel (prizlo-cel), an autologous dual targeting chimeric antigen receptor (CAR) T-cell therapy targeting both cluster of differentiation (CD) CD20 and CD19, for the treatment of adult participants with relapsed or refractory (r/r) B-Cell non-Hodgkin lymphoma (B-NHL) or frontline high-risk diffuse large B-cell lymphoma (DLBCL).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participant must be greater than or equal to (>=) 18 years of age, at the time ofsigning informed consent

  • Tumor must be histologically confirmed cluster of differentiation (CD)19 and/or CD20positive

  • Must meet the indications for each subtype in Phase 1b as specified in protocol andPhase 2 participants must have following: Diagnosis of Large B-cell lymphoma (LBCL),Follicular large B-cell lymphoma (FLBCL), or transformation of indolent lymphoma;Received at least 2 prior lines of systemic therapy; Relapsed or refractory diseasedefined as 1 or more of the following: Stable disease or Progressive disease (PD) asbest response to most recent anti-lymphoma therapy OR disease progression orrecurrence after a partial response (PR) or complete response (CR) to most recentanti lymphoma therapy; cohort specific requirements as mentioned in protocol

  • Measurable disease as defined by Lugano 2014 classification

  • Eastern cooperative oncology group (ECOG) performance status of 0 to 2

Exclusion

Exclusion Criteria:

  • History of symptomatic deep vein thrombosis or pulmonary embolism within six monthsof apheresis (line associated deep vein thrombosis is allowed)

  • History of stroke, unstable angina, myocardial infarction, congestive heart failureNew York Heart Association (NYHA) Class III or IV, severe cardiomyopathy orventricular arrhythmia requiring medication or mechanical control within 6 months ofapheresis

  • History of a seizure disorder, dementia, cerebellar disease or neurodegenerativedisorder

  • Known history or prior diagnosis of optic neuritis or other immunologic orinflammatory disease affecting the central nervous system

  • Current active liver or biliary disease (except for Gilbert's syndrome orasymptomatic gallstones)

  • Evidence of active viral or bacterial infection requiring systemic antimicrobialtherapy, or uncontrolled systemic fungal infection

  • Diagnosis of Human herpes virus (HHV) 8-positive DLBCL or T cell/histiocyte-richlarge B-cell lymphoma or Burkitt and high-grade B-cell lymphoma with 11q aberrations (previously Burkitt-like lymphoma) or Richter's transformation or Lymphomatoidgranulomatosis or Plasmablastic lymphoma or Waldenstrom's Macroglobulinemia

  • Any prior solid organ or allogeneic stem cell transplantation

  • Autologous stem cell transplant within 12 weeks of apheresis; Prior CAR-T celltherapy within 12 weeks of apheresis

Study Design

Total Participants: 439
Treatment Group(s): 2
Primary Treatment: Prizloncabtagene autoleucel (Prizlo-Cel)
Phase: 1/2
Study Start date:
August 12, 2022
Estimated Completion Date:
March 12, 2029

Connect with a study center

  • St Vincents Hospital Melbourne

    Fitzroy, 3065
    Australia

    Active - Recruiting

  • St. Vincent's Hospital Melbourne

    Fitzroy, 3065
    Australia

    Active - Recruiting

  • St Vincents Hospital Melbourne

    Fitzroy 2166584, 3065
    Australia

    Site Not Available

  • The Alfred Hospital

    Melbourne, 3004
    Australia

    Active - Recruiting

  • The Alfred Hospital

    Melbourne 2158177, 3004
    Australia

    Site Not Available

  • Fiona Stanley Hospital

    Murdoch, 6150
    Australia

    Active - Recruiting

  • Fiona Stanley Hospital

    Murdoch 8349091, 6150
    Australia

    Site Not Available

  • Calvary Mater Newcastle Hospital

    Waratah, 2298
    Australia

    Completed

  • Calvary Mater Newcastle Hospital

    Waratah 10103871, 2298
    Australia

    Site Not Available

  • Princess Margaret Cancer Centre University Health Network

    Toronto, Ontario M5G2M9
    Canada

    Active - Recruiting

  • Princess Margaret Cancer Centre University Health Network

    Toronto 6167865, Ontario 6093943 M5G2M9
    Canada

    Site Not Available

  • Rigshospitalet

    Copenhagen, 2100
    Denmark

    Active - Recruiting

  • Rigshospitalet

    Copenhagen 2618425, 2100
    Denmark

    Site Not Available

  • Odense University Hospital

    Odense, 5000
    Denmark

    Active - Recruiting

  • Odense University Hospital

    Odense 2615876, 5000
    Denmark

    Site Not Available

  • Asan Medical Center

    Seoul, 05505
    Korea, Republic of

    Active - Recruiting

  • Samsung Medical Center

    Seoul, 06351
    Korea, Republic of

    Site Not Available

  • Seoul National University Hospital

    Seoul, 03080
    Korea, Republic of

    Active - Recruiting

  • Erasmus MC

    Rotterdam, 3015 GD
    Netherlands

    Active - Recruiting

  • Erasmus MC

    Rotterdam 2747891, 3015 GD
    Netherlands

    Site Not Available

  • UMC Utrecht

    Utrecht, 3584 CX
    Netherlands

    Active - Recruiting

  • UMC Utrecht

    Utrecht 2745912, 3584 CX
    Netherlands

    Site Not Available

  • Asan Medical Center

    Seoul, 05505
    South Korea

    Active - Recruiting

  • Samsung Medical Center

    Seoul, 06351
    South Korea

    Active - Recruiting

  • Seoul National University Hospital

    Seoul, 03080
    South Korea

    Active - Recruiting

  • Asan Medical Center

    Seoul 1835848, 05505
    South Korea

    Site Not Available

  • Samsung Medical Center

    Seoul 1835848, 06351
    South Korea

    Active - Recruiting

  • Seoul National University Hospital

    Seoul 1835848, 03080
    South Korea

    Active - Recruiting

  • Hosp Clinic de Barcelona

    Barcelona, 08036
    Spain

    Active - Recruiting

  • Hosp Univ Vall D Hebron

    Barcelona, 08035
    Spain

    Active - Recruiting

  • ICO L'Hospitalet - Hospital Duran i Reynals

    Barcelona, 08908
    Spain

    Active - Recruiting

  • Hosp Clinic de Barcelona

    Barcelona 3128760, 08036
    Spain

    Active - Recruiting

  • Hosp Univ Vall D Hebron

    Barcelona 3128760, 08035
    Spain

    Active - Recruiting

  • ICO L'Hospitalet - Hospital Duran i Reynals

    Barcelona 3128760, 08908
    Spain

    Site Not Available

  • Hosp Univ Fund Jimenez Diaz

    Madrid, 28040
    Spain

    Active - Recruiting

  • Hosp Univ Fund Jimenez Diaz

    Madrid 3117735, 28040
    Spain

    Site Not Available

  • University College London Hospitals

    London, NW1 2BU
    United Kingdom

    Active - Recruiting

  • University College London Hospitals

    London 2643743, NW1 2BU
    United Kingdom

    Site Not Available

  • The Christie NHS Foundation Trust Christie Hospital

    Manchester, M20 4BX
    United Kingdom

    Active - Recruiting

  • The Christie NHS Foundation Trust Christie Hospital

    Manchester 2643123, M20 4BX
    United Kingdom

    Site Not Available

  • City of Hope

    Duarte, California 91010
    United States

    Active - Recruiting

  • City of Hope Medical Center

    Duarte, California 91010-3000
    United States

    Active - Recruiting

  • City of Hope

    Duarte 5344147, California 5332921 91010
    United States

    Site Not Available

  • Colorado Blood Cancer Institute

    Denver, Colorado 80218
    United States

    Active - Recruiting

  • Colorado Blood Cancer Institute

    Denver 5419384, Colorado 5417618 80218
    United States

    Site Not Available

  • Northwestern University

    Chicago 4887398, Illinois 4896861 60611
    United States

    Site Not Available

  • University of Iowa Hospital and Clinics

    Iowa City, Iowa 52242
    United States

    Active - Recruiting

  • University of Iowa Hospital and Clinics

    Iowa City 4862034, Iowa 4862182 52242
    United States

    Site Not Available

  • University of Kentucky Medical Center

    Lexington, Kentucky 40536
    United States

    Active - Recruiting

  • University of Kentucky Medical Center

    Lexington 4297983, Kentucky 6254925 40536
    United States

    Site Not Available

  • Rutgers Cancer Institute of New Jersey

    Piscataway, New Jersey 08854
    United States

    Active - Recruiting

  • Rutgers Cancer Institute of New Jersey

    Piscataway 5102713, New Jersey 5101760 08854
    United States

    Site Not Available

  • Levine Cancer Institute

    Charlotte, North Carolina 28001
    United States

    Active - Recruiting

  • Levine Cancer Institute

    Charlotte 4460243, North Carolina 4482348 28001
    United States

    Site Not Available

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio 44106
    United States

    Active - Recruiting

  • University Hospitals Cleveland Medical Center

    Cleveland 5150529, Ohio 5165418 44106
    United States

    Site Not Available

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania 15232
    United States

    Active - Recruiting

  • University of Pittsburgh Medical Center

    Pittsburgh 5206379, Pennsylvania 6254927 15232
    United States

    Site Not Available

  • Greco Hainesworth Tennessee Oncology Centers for Research

    Nashville, Tennessee 37203
    United States

    Active - Recruiting

  • Sarah Cannon Research Institute

    Nashville, Tennessee 37203
    United States

    Active - Recruiting

  • Greco Hainesworth Tennessee Oncology Centers for Research

    Nashville 4644585, Tennessee 4662168 37203
    United States

    Site Not Available

  • Sarah Cannon Research Institute

    Nashville 4644585, Tennessee 4662168 37203
    United States

    Active - Recruiting

  • St. David's South Austin Medical Center

    Austin, Texas 78704
    United States

    Active - Recruiting

  • Texas Transplant Institute

    San Antonio, Texas 78229
    United States

    Active - Recruiting

  • St. David's South Austin Medical Center

    Austin 4671654, Texas 4736286 78704
    United States

    Site Not Available

  • Texas Transplant Institute

    San Antonio 4726206, Texas 4736286 78229
    United States

    Site Not Available

  • VCU Medical Center

    Richmond 4781708, Virginia 6254928 23219
    United States

    Site Not Available

  • Swedish Cancer Institute

    Seattle, Washington 98104
    United States

    Active - Recruiting

  • Swedish Cancer Institute

    Seattle 5809844, Washington 5815135 98104
    United States

    Site Not Available

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