Phase
Condition
Lymphoma
Lymphoma, B-cell
Treatment
JNJ-90014496
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Participant must be greater than or equal to (>=) 18 years of age, at the time ofsigning informed consent
Tumor must be histologically confirmed cluster of differentiation (CD)19 and/or CD20positive
Must meet the following indications for each subtype: Relapsed or refractory matureaggressive large B cell non-Hodgkin lymphoma (NHL) and follicular lymphoma Grade 3b:Participants must have had >= 2 lines of systemic therapy or >= 1 line of systemictherapy in case of participants ineligible for high-dose chemotherapy and autologoushematopoietic stem cell transplantation (HSCT); Relapsed or refractory follicularlymphoma Grade 1-3a and marginal zone lymphoma: Participants must have had >= 2prior lines of anti-neoplastic systemic therapy. Participants also must have priorexposure to an anti-CD20 monoclonal antibody
Frontline high-risk diffuse large B Cell lymphoma (DLBCL): Participants must haveDLBCL or high-grade B-cell lymphoma (HGBCL) with residual lymphoma by positiveinterim positron emission computed tomography 2 or 3 cycles of frontlinechemoimmunotherapy. Participants must have only received 2 or 3 cycles of frontlinechemoimmunotherapy for DLBCL
Measurable disease as defined by Lugano 2014 classification
Eastern cooperative oncology group (ECOG) performance status of either 0 or 1. ECOGof 0 to 2 is allowed in frontline high-risk DLBCL cohort
Exclusion
Exclusion Criteria:
Diagnosis of Human herpes virus (HHV) 8-positive DLBCL or T cell/histiocyte-richlarge B-cell lymphoma
Any prior solid organ or allogeneic stem cell transplantation
Autologous stem cell transplant within 12 weeks of chimeric antigen receptor (CAR) Tcell infusion
Uncontrolled active infections
History of deep vein thrombosis or pulmonary embolism within six months of infusion (except for line associated deep vein thrombosis [DVT])
History of stroke, unstable angina, myocardial infarction, congestive heart failureNew York Heart Association (NYHA) Class III or IV, severe cardiomyopathy orventricular arrhythmia requiring medication or mechanical control within 6 months ofscreening
History of a seizure disorder, dementia, cerebellar disease or neurodegenerativedisorder
Known history or prior diagnosis of optic neuritis or other immunologic orinflammatory disease affecting the central nervous system
Current active liver or biliary disease (except for Gilbert's syndrome orasymptomatic gallstones)
Study Design
Connect with a study center
St Vincents Hospital Melbourne
Fitzroy, 3065
AustraliaActive - Recruiting
St. Vincent's Hospital Melbourne
Fitzroy, 3065
AustraliaActive - Recruiting
The Alfred Hospital
Melbourne, 3004
AustraliaActive - Recruiting
Fiona Stanley Hospital
Murdoch, 6150
AustraliaActive - Recruiting
Calvary Mater Newcastle Hospital
Waratah, 2298
AustraliaActive - Recruiting
Princess Margaret Cancer Centre University Health Network
Toronto, Ontario M5G2M9
CanadaActive - Recruiting
Rigshospitalet
Copenhagen, 2100
DenmarkActive - Recruiting
Odense University Hospital
Odense, 5000
DenmarkActive - Recruiting
Asan Medical Center
Seoul, 05505
Korea, Republic ofActive - Recruiting
Samsung Medical Center
Seoul, 06351
Korea, Republic ofActive - Recruiting
Seoul National University Hospital
Seoul, 03080
Korea, Republic ofActive - Recruiting
Erasmus MC
Rotterdam, 3015 GD
NetherlandsActive - Recruiting
UMC Utrecht
Utrecht, 3584 CX
NetherlandsActive - Recruiting
Hosp Clinic de Barcelona
Barcelona, 08036
SpainActive - Recruiting
Hosp Univ Vall D Hebron
Barcelona, 08035
SpainActive - Recruiting
ICO L'Hospitalet - Hospital Duran i Reynals
Barcelona, 08908
SpainActive - Recruiting
Hosp Univ Fund Jimenez Diaz
Madrid, 28040
SpainActive - Recruiting
University College London Hospitals
London, NW1 2BU
United KingdomActive - Recruiting
The Christie NHS Foundation Trust Christie Hospital
Manchester, M20 4BX
United KingdomActive - Recruiting
City of Hope
Duarte, California 91010
United StatesActive - Recruiting
City of Hope Medical Center
Duarte, California 91010-3000
United StatesActive - Recruiting
Colorado Blood Cancer Institute
Denver, Colorado 80218
United StatesActive - Recruiting
University of Iowa Hospital and Clinics
Iowa City, Iowa 52242
United StatesActive - Recruiting
Rutgers Cancer Institute of New Jersey
Piscataway, New Jersey 08854
United StatesActive - Recruiting
Levine Cancer Institute
Charlotte, North Carolina 28001
United StatesActive - Recruiting
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania 15232
United StatesActive - Recruiting
Sarah Cannon Research Institute
Nashville, Tennessee 37203
United StatesActive - Recruiting
St. David's South Austin Medical Center
Austin, Texas 78704
United StatesActive - Recruiting
Texas Transplant Institute
San Antonio, Texas 78229
United StatesActive - Recruiting
Swedish Cancer Institute
Seattle, Washington 98104
United StatesActive - Recruiting
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