A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

Inclusion Criteria:

• Histologic diagnosis of small cell lung cancer

• Radiographic diagnosis of up to 20 brain metastases on contrast-enhanced MRI

• Age 18 and above

• Performance status KPS 60-100/ECOG 0-2

• Female patients must be of non-reproductive potential or have a negative serumpregnancy test at the time of enrollment

• The patient or legally authorized representative is able to provide informed consent

Exclusion Criteria:

• Unable to undergo contrast-enhanced MRI brain

• Leptomeningeal disease confirmed on lumbar puncture, MRI brain, or MRI spine

• Pregnant or lactating women

• Prior brain-directed radiotherapy

• Uncontrolled systemic disease without reasonable systemic therapy options feltlikely to result in death as observed on CT or PET/CT imaging, no more than 3 monthsbefore study enrollment