Phase
Condition
Lung Disease
Treatment
Dotarem
[68Ga]CBP8
Clinical Study ID
Ages > 40 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Group 1: First degree relatives of a family member with pulmonary fibrosis (n=8)
Age greater than 40 years
Have the ability to give written informed consent
First degree relative of a family member with pulmonary fibrosis
No known history of interstitial lung disease
No tobacco use within the prior 6 months.
Group 2: Subjects with interstitial lung abnormalities (ILAs) or interstitial lung disease (ILD) (n=22)
Age greater than 40 years
Have the ability to give written informed consent
ILAs or early ILD (defined by presence of reticular markings and / or tractionbronchiectasis but absence of a definite UIP pattern)
No tobacco use within the prior 6 months.
Exclusion
Exclusion criteria:
Electrical implants such as cardiac pacemaker or perfusion pump
Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses,artificial hearts, valves with steel parts, metal fragments, shrapnel, metallictattoos anywhere on the body, tattoos near the eye, or steel implants ferromagneticobjects such as jewelry or metal clips in clothing
Historical eGFR of less than 30 mL/min/1.73 m2
Pregnant or breastfeeding (a negative quantitative serum hCG pregnancy test isrequired for females having child-bearing potential before the subject canparticipate)
Claustrophobic reactions
Research-related radiation exposure exceeds current Radiology Department guidelines (i.e. 50 mSv in the prior 12 months)
Unable to lie comfortably on a bed inside the MR-PET
BMI > 33 (limit of the PET-MRI table)
Determined by the investigator(s) to be clinically unsuitable for the study (e.g.based on screening visit and/or during study procedures)
Pneumonia or other acute respiratory illness within 6 weeks of study entry
Parenchymal lung disease except for ILD/ILAs or emphysema
Acute exacerbation of ILD within the prior 6 months
VATS within the prior 6 months
Prior radiation therapy to the thorax
Known allergy to gadolinium.
Study Design
Study Description
Connect with a study center
Massachusetts General Hospital
Boston, Massachusetts 02114
United StatesActive - Recruiting


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