Non-invasive Left Ventricle Contractility dp/dt as Prognostic Marker in Chest Unit Patients

Last updated: May 13, 2023
Sponsor: University of Monastir
Overall Status: Active - Recruiting

Phase

N/A

Condition

Chest Pain

Treatment

N/A

Clinical Study ID

NCT05416112
dp/dt
  • Ages > 18
  • All Genders

Study Summary

Ischemic heart disease is a major public health problem with high mortality rate despite the progress in management and the resources mobilized. The idea is that myocardial ischemia is generally associated with left ventricular dysfunction and, consequently, a possible alteration of the dp/dt index. As dp/dt could be assessed non-invasively by plethysmographic method, it is interesting to investigate its prognostic performance in patients with indifferentiate chest pain.

Eligibility Criteria

Inclusion

Inclusion criteria:

  • age over 18 years old,
  • acute chest pain

Exclusion

Exclusion criteria:

  • traumatic chest pain,
  • hemodynamic instability;
  • arrhythmias;
  • holders of a pacemaker;
  • STEMI

Study Design

Total Participants: 500
Study Start date:
June 01, 2022
Estimated Completion Date:
September 30, 2023

Study Description

Ischemic heart disease remains a major public health problem. Despite all the advances in the prognostic approach to ischemic heart disease, the risk of occurrence of major cardiovascular events is not negligible. Several scores have been proposed for chest pain stratification risk, the most widely used are the TIMI and the GRACE scores.

The dP/dt max is therefore an excellent index of contractility, corresponding to the maximum level of tension developed by an isolated cardiac muscle during the isovolumic contraction phase.

the investigator theorized that a less value of dp/dt would be associated with more major cardiovascular events (MACE), because ischemia reduces myocardial contractility.

The current study describes non-invasive plethysmographic dp/dt changes, which could be used as a prognostic marker in patients presenting at the emergency department with acute chest pain.

Connect with a study center

  • Emergency Departement

    Monastir, 5000
    Tunisia

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.