Assessment of the Effects on the Skin Microbiome of Amending an Over-the-counter Eczema Product With Activated Oil (AO)

Inclusion Criteria:

• Provision of signed and dated informed consent form.
• Stated willingness to comply with all study procedures and availability for theduration of the study.
• Male or female subjects aged who have a recent eczema itch flareup and/or pre-flare-upsymptoms at screening as determined by visual analog scale (VAS).
• Diagnosis of mild to moderate eczema (grade 3 - 7 on the Rajka-Langeland severityindex).
• Having a target lesion with an ADSI score of 6-12 and an erythema and pruritussubscore of ³2 (moderate).
• Generally good health based on reported history.
• Able to discontinue all medical and over the counter topical emollients, moisturizers,and / or other skin barrier lotions.
• Females of child-bearing potential should agree to continue using a medicallyacceptable method of birth control throughout the study and for 30 days immediatelyafter the last dose of study drug.
• Ability to administer topical medication and be willing to adhere to the studyinterventions.
• Agreement to adhere to Lifestyle Considerations throughout the duration of the study.

Exclusion Criteria:

• Pregnancy or lactation.
• Any type of malignancy involving the Study Site Area (Lesion or Non-Lesion site) inthe last 5 years.
• Known allergy to hydrocortisone or topical antibiotic.
• Topical or oral use of an antibiotic within the last 7 days prior to baseline clinicalvisit.
• Bleach bathing in the 7 days prior to Baseline clinical visit.
• Current use of Class I-III topical corticosteroids or systemic medications (e.g.Dupixent) potentially affecting eczema or the skin.
• Surgeries or invasive medical procedures planned during course of study.
• Suspected non-compliance or non-cooperation.
• Intake of experimental drugs or experimental topical skin treatments within 30 daysprior to study start.
• Mental disability or any other lack of fitness, in the Investigator's opinion, topreclude subject's participation in or ability to complete the study.
• Diagnosis of human immunodeficiency virus in medical history.