Study to Assess Change in Disease Activity and Adverse Events of Ab Externo Approach for Glaucoma Gel Stent (XEN45) Implantation In Participants Aged 45 Years or Older With Open-Angle Glaucoma

Inclusion Criteria:

• Glaucoma in the study eye.

1. Study eye diagnosed with open-angle glaucoma uncontrolled by medical therapy

2. Study eye that meet at least one of the following criteria:

• Failed one or more incisional intraocular glaucoma surgeries (e.g.,glaucoma filtering surgery or tube shunt) (a minimum of approximately 15subjects will be enrolled)
• Failed one or more cilioablative procedures (e.g., cryotherapy, cyclodiodetherapy)
• Have neovascular glaucoma
• Have any other condition (e.g., conjunctival scarring, uveitis) in which aconventional incisional glaucoma surgery like trabeculectomy would be morelikely to fail than for a person with uncomplicated primary open-angleglaucoma (OAG).Note: To allow for a subgroup of participants who only have OAG uncontrolled bymedical therapy (non-refractory glaucoma), a maximum of 10 participants whomeet only criterion a (and not b) will be enrolled.

Exclusion Criteria:

• A lack of healthy conjunctiva showing free mobility (free of scarring or evidence ofprior surgery) in the target area.

• Excessive intraoperative bleeding, such that visualization in the study eye isimpaired.

• Any anatomy or finding in the study eye that limits the investigator's ability tovisualize the anterior chamber, angle, or target area of the conjunctiva.

• Other surgical complication that in the opinion of the investigator could impedeproper placement of the Gel Stent.