Tenofovir Alafenamide Switching Therapy in Kidney or Liver Transplant Recipients with Chronic HBV Infection

Last updated: January 7, 2025
Sponsor: Taichung Veterans General Hospital
Overall Status: Active - Not Recruiting

Phase

4

Condition

Hepatitis

Hepatitis B

Organ Transplant

Treatment

Tenofovir Alafenamide 25 MG

Clinical Study ID

NCT05410496
CF21160B
  • Ages > 20
  • All Genders

Study Summary

tenofovir alafenamide (TAF) has been approved to be highly effective and safe in patients with chronic hepatitis B (CHB), therefore TAF may be a good option in kidney or liver transplant patients with chronic HBV infection. The aim of this prospective cohort study is to assess the safety, efficacy, and drug adherence improvement of TAF switching therapy in kidney or liver transplant patients with HBV infection.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. At least 20 years of age

  2. Chronic HBV infection under NA therapy other than TAF

  3. Underwent kidney and/ or liver transplantation

  4. Without clinical or pathologic evidence of moderate or severe rejection

  5. Patients who are indicated for TAF switching therapy, such as concerns invirological response, biochemical response, drug compliance, or safety issues toother NAs.

Exclusion

Exclusion Criteria:

  1. End stage renal disease (eGFR < 15 mL/min/1.73m2)

  2. Co-infected with human immunodeficiency virus (HIV) or hepatitis C virus (HCV)

  3. Any active malignancies

  4. Pregnant or breast-feeding women

  5. Known allergy to tenofovir-contained regimens

Study Design

Total Participants: 52
Treatment Group(s): 1
Primary Treatment: Tenofovir Alafenamide 25 MG
Phase: 4
Study Start date:
June 22, 2021
Estimated Completion Date:
July 30, 2027

Study Description

Life-long nucleos(t)ide analogue (NA) therapy has been recommended in patients with chronic HBV infection after organ transplantation, therefore the safety of long-term NA therapy is particularly important in transplant patients. Entecavir, tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF) are recommended drugs for CHB patients in current guidelines because of their high potency in antiviral efficacy and low rate in virological resistance. However, the data of TAF therapy in transplant patients remain limited.

The potential nephrotoxicity and a decrease in bone mineral density (BMD) of TDF therapy have been reported in previous studies. TAF is a novel prodrug of tenofovir and is formulated to deliver the active metabolite to target cells more efficiently than TDF at a much lower dose, thereby reducing systemic exposure to tenofovir. In the randomized controlled trials of TDF versus TAF showed that virological and serological results were similar in both arms. However, patients in TAF arm had improved renal effects and BMD as compared to TDF. Improvement in renal function and BMD were also found in chronic hepatitis B patients who switched from TDF to TAF. Furthermore, in some retrospective studies, switching from entecavir to TAF may present a superior efficacy in HBV DNA suppression and HBsAg level reduction, and renal safety was comparable between the TAF switch group and the entecavir continuation group. Interestingly, switching from entecavir to TAF is associated with improvement of the medication adherence, which may be particularly important to patients under long-term NA therapy.

The clinical data of TAF therapy in transplant patients remain very limited, particularly in kidney transplant patients. With a high virological response rate and a low adverse effect (AE) rate in patients with CHB, TAF may be a good option for patients underwent liver or kidney transplantation.The aim of this study is to assess the safety, drug adherence, and efficacy of TAF switching therapy in kidney or liver or transplant patients with chronic HBV infection.

Connect with a study center

  • China Medical University Hospital

    Taichung, 40447
    Taiwan

    Site Not Available

  • Taichung Veterans General Hospital

    Taichung, 40705
    Taiwan

    Site Not Available

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