Targeting Inflammation for Endometrial Cancer Prevention

Last updated: July 9, 2025
Sponsor: Mayo Clinic
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Carcinoma

Dysfunctional Uterine Bleeding

Inflammation

Treatment

Biospecimen Collection

Questionnaire Administration

Clinical Study ID

NCT05407025
21-001880
NCI-2021-14231
  • Ages > 18
  • Female
  • Accepts Healthy Volunteers

Study Summary

This study examines risk assessment and identifies prevention strategies for endometrial cancer. Collecting samples of blood and urine and risk assessments from patients with benign conditions or endometrial cancer may help doctors learn if there is a relationship between chronic inflammation and increase in risk for endometrial cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Women over the age of 18 years old undergoing hysterectomy for any benign indicationor endometrial cancer

Exclusion

Exclusion Criteria:

  • Men

  • Women under the age of 18 years

  • Women with a history of cancer, except for endometrial cancer or non-melanoma skincancer

  • Women with type 1 diabetes

  • Women that have received radiation or chemotherapy for cancer

Study Design

Total Participants: 191
Treatment Group(s): 2
Primary Treatment: Biospecimen Collection
Phase:
Study Start date:
December 01, 2021
Estimated Completion Date:
December 31, 2027

Study Description

PRIMARY OBJECTIVE:

I. To develop a model for a biobank that can be expanded across the Mayo Enterprise and implemented at extramural collaborative sites, including underserved populations.

OUTLINE: This is an observational study.

Patients complete a risk factor questionnaire over 15 minutes. Patients also undergo collection of blood and urine during pre-operative visit and collection of tissue samples at the time of surgery.

Connect with a study center

  • Mayo Clinic in Arizona

    Scottsdale, Arizona 85259
    United States

    Site Not Available

  • Mayo Clinic in Florida

    Jacksonville, Florida 32224-9980
    United States

    Site Not Available

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