Mepolizumab and Physical Activity in Severe Asthma

Inclusion Criteria:

• Age between 18 and 75 years at the time of inclusion

• Asthma diagnosed for at least one year including a history of

1. FEV1 and/or FVC reversibility of more than 12% and than 200 ml documented inthe patient's record

2. OR FEV1 variability of more than 20% between two visits

3. OR positive methacholine test

• Severe uncontrolled asthma monitored for at least six months in the investigationcenter with at least two assessments:

1. high-dose of inhaled corticosteroids (ICS >1,000 μg/day of beclometasoneequivalent) in combination with another controller at a stable dosage for atleast three months

2. ACQ-5 score >1.5 and/or more than two severe exacerbations (i.e exacerbationrequiring ≥ 3 days of systemic corticosteroids, hospitalization or admission atthe emergency department) in the past year

3. Blood eosinohils ≥300/mm3 within the 12 past months

4. Decision to introduce mepolizumab according to regulatory approval

5. Patient agreement to receive Mepolizumab

• Body mass index (BMI) within the range [18.5 - 35] kg/m2.

• Able to give signed informed consent which includes compliance with the requirementsand restrictions listed in the informed consent form (ICF) and in this protocol

Exclusion Criteria:

• Body Mass Index <18.5 or >35 kg/m2

• Active smoker or active smoking during the last 6 months or cumulative > 10pack-years

• All conditions responsible for physical disability (neurological, orthopedic,psychiatric, non-exhaustive list) or other condition limiting exercise in theinvestigator's opinion

• Any chronic respiratory or cardiac pathology which may interfere with the assessmentof asthma according to the investigator's opinion

• Prior treatment with mepolizumab or benralizumab

• Bronchial thermoplasty during the past 12 months

• Contraindication to mepolizumab

• Non-coverage by the social security insurance

• Pregnant, breastfeeding, or lactating women

• Patient unable to receive information

• Refusal to sign the consent form

• Unwillingness or inability to follow the study procedures, in the opinion of theinvestigator

• Person deprived of the liberty Person benefiting from a system of legal protection (guardianship...)