Dynamics of Immune Map and Outcomes After On-pump Cardiac Surgery: Protocol for a Prospective Cohort Study

Last updated: February 18, 2023
Sponsor: West China Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT05400356
WCH
  • Ages > 18
  • All Genders

Study Summary

Although systemic inflammatory response induced by cardiopulmonary bypass is believed as one of main reasons for these adverse events, the involved mechanism is still unclear.This cohort study would include patients undergoing on-pump valve surgery or CABG. By detecting the changes of immune cell expression profile and inflammatory related substances in blood, the spatiotemporal change curve of immune function of patients is drawn for avoiding or treating adverse events.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • (1) participants aged over 18 years; (2) Participants who scheduled for valvereplacement or valvuloplasty, coronary artery bypass under CPB.

Exclusion

Exclusion Criteria:

  • (1) participant with a cognitive or mental disorder who is unable to sign an informedconsent form; (2) suffering from basic immune system and blood system diseases; (3)pregnancy; (4) preoperative radiotherapy and chemotherapy; (5) receiveimmunosuppressive drugs within six months;(6) Expected survival time less than 2years;(7) participated in other intervention clinical trials within 30 days beforeoperation.

Study Design

Total Participants: 120
Study Start date:
June 01, 2022
Estimated Completion Date:
March 31, 2023

Connect with a study center

  • West China Hospital of Sichuan University

    Chengdu, Sichuan 610044
    China

    Active - Recruiting

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