Left Ventricular Global Longitudinal Strain and Postoperative Myocardial Injury

Last updated: June 17, 2022
Sponsor: The Second Affiliated Hospital of Chongqing Medical University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT05392426
GLS and Myocardial injury
  • Ages 65-90
  • All Genders

Study Summary

To use left ventricular global longitudinal strain as a means of monitoring myocardial exercise function during anaesthesia in patients with coronary artery disease, to explore the association with the occurrence of postoperative myocardial injury, and to perform a predictive study of postoperative myocardial injury. The study was designed according to a prospective follow-up cohort.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age 65-90;
  2. According to the European Heart Association's diagnostic criteria for chronic coronarysyndrome in 2019.Patients with suspected coronary heart disease and stable anginapectoris, with or without dyspnea; New heart failure or left ventricular dysfunction,suspected coronary heart disease; Patients with acute coronary syndrome who areasymptomatic or stable within one year of onset, or who will undergo revascularizationin the near future;Patients with an initial diagnosis or revascularization for morethan one year, with or without symptoms; Angina pectoris, suspected vasospasm, ormicrovascular disease patients; During screening, asymptomatic people with coronaryheart disease were discovered;
  3. ASA IIIII; NYHA IIIII; require general anesthesia;
  4. no history of anesthetic allergy;
  5. agreed to participate in the study and signed the informed consent form.

Exclusion

Exclusion Criteria:

  1. Congenital heart disease, severe ventricular arrhythmia, atrial fibrillation, severevalvular regurgitation;
  2. Severe history of chronic obstructive pulmonary illness (COPD severity III or IV),individuals with severe or uncontrolled bronchial asthma, pulmonary infection,bronchiectasis;
  3. Patients with persistent drinking and known or suspected abusers of other narcoticanalgesics;
  4. Obese (BMI 30 kg/m2)
  5. Cardiac surgical procedures are planned.

Study Design

Total Participants: 58
Study Start date:
May 30, 2022
Estimated Completion Date:
June 01, 2023

Study Description

The incidence and risk of postoperative myocardial injury in patients with coronary artery disease is high, and there is no definitive monitoring tool to predict postoperative myocardial injury. Speckle tracking imaging (STI), which quantifies strain and ventricular torsion in all segments of the heart, is more sensitive to subtle changes in myocardial contractility than conventional ultrasound. This project proposes to use 4D-STI as a means of monitoring myocardial exercise function during anaesthesia in patients with coronary artery disease, to explore the association with the occurrence of postoperative myocardial injury, and to perform a predictive study of postoperative myocardial injury. The study was designed according to a prospective follow-up cohort. The protocol was developed with reference to the STROBE guidelines for cohort studies. In this study, 2.5 ml of venous blood specimens were collected before surgery and at the end of surgery and sent to the laboratory. Intraoperative data collection was performed in the operating theatre and follow-up was obtained on the ward and during telephone follow-up.

Connect with a study center

  • Department of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University

    Chongqing, Chongqing 400010
    China

    Active - Recruiting

  • The second affiliated hospital of Chongqing medical university

    Chongqing,
    China

    Active - Recruiting

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