AI for Anti-hypertensive Medication Titration

Inclusion Criteria:

• At least >=30 years of age and <=80 years
• History of uncontrolled primary hypertension, BPs more >=140/90mm Hg, treatment-naiveor on single antihypertensive medication
• Not known to have complications of hypertension
• Sufficiently fluent in English language
• Able to give informed consent
• eGFR > 60 ml/min
• Eligible to undergo CCB + ARB/ACE-i therapy for =30 days

Exclusion Criteria:

• Suspected or known secondary hypertension
• Drug allergies to anti-hypertensive agents or agents of the same drug class used inthe protocol
• Known postural hypotension or standing systolic blood pressure < 110 mmHg
• Malignant hypertension (BPs = 180/110 mmHg) that requires emergency treatment
• Arm circumference that does not fit BP cuff size which can affect the accuracy of BPmeasurement
• Pregnant women, trying to become pregnant or of child-bearing potential and not usingbirth control
• History of cancer
• Chronic kidney disease (eGFR <50ml/min) or end stage renal failure
• Liver cirrhosis or hepatic failure
• Chronic heart failure
• Chronic lung disease
• Diabetes Mellitus on insulin and/or with microvascular/macrovascular complications.
• Established cardiovascular disease such as stroke/transient ischemic attack andischemic heart disease
• Potential psychosocial factors or serious medical conditions limiting the ability toself-monitor their blood pressure or limit adherence to interventions (E.g. dementia,active substance abuse, nursing home resident)
• Participants without informed consent