StimAire Sleep Study

Inclusion Criteria:

1. Obstructive Sleep Apnea (defined by AHI > 15 and < 50 per hour of sleep withnon-supine AHI>10; with hypopneas defined as greater than 30% reduction in airflowwith 3% or greater drop in oxygen saturation). AHI will be determined by full nightpolysomnography as per guidelines of the American Academy of Sleep Medicine.
2. Age range > 18 years.
3. Difficulty accepting or adhering to, or not desiring of, CPAP therapy.
4. Participant has willingly consented to participate in the study.
5. Participant is willing to remove or have removed facial hair between the base of theneck and the mandible.

Exclusion Criteria:

1. Body mass index > 32 kg/m2. Obese individuals are less responsive to OSAneurostimulation.
2. Documented central or complex sleep apnea > 5 per hour.
3. Participants with pacemaker, defibrillator, or implanted neurostimulators.
4. Hypoxemic and requiring oxygen supplementation.
5. Prior diagnosis of Decompensated cardiac (heart failure [New York heart AssociationCategory III or IV]; or angina) or pulmonary (severe COPD or uncontrolled asthma)disease.
6. Prior diagnosis of any moderate to severe pulmonary artery hypertension.
7. Diagnosis of another sleep disorder in addition to OSA based on PSG (e.g., periodiclimb movement arousal index > 10, insomnia, obesity hypoventilation syndrome, ornarcolepsy).
8. Hypoglossal nerve palsy on either hypoglossal nerve.
9. Prior diagnosis of neuromuscular disease.
10. Recent or recurring history of recreational drug use leading to tolerance ordependence, at the discretion of the investigators
11. Prior diagnosis of persistent uncontrolled hypertension despite antihypertensivemedication use.
12. Any unstable medical or psychiatric comorbidity at the discretion of the investigators
13. Actively taking anticoagulation medication
14. Aspirin taken within 2 weeks prior to injection at the discretion of the investigators
15. Bilateral or unilateral pathology in the submandibular space
16. Actively participating in another clinical trial that to the investigators opinion maycompromise this study results.
17. Hypoglossal nerve depth greater than 2.5 cm at the target location of the stimulatingelectrode as observed on ultrasound display.
18. Tonsil size of 3 or 4 (tonsils visible beyond the pillars or extending to midline) oranother anatomical obstruction, at the discretion of the investigators
19. The participant is not appropriate for the regimen for another reason, at thediscretion of the investigators