A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure on TLD in Sub-Saharan Africa

Last updated: March 3, 2025
Sponsor: Massachusetts General Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hiv Infections

Hiv

Treatment

Immediate Switch

Standard of Care treatment strategy

Maintenance on TLD treatment strategy

Clinical Study ID

NCT05373758
2022P001193
R01AI167699
  • Ages > 15
  • All Genders

Study Summary

The RESOLVE trial is an open, parallel arm, randomized clinical trial which aims to determine the optimal strategy for management of virologic failure on antiretroviral therapy (ART) with tenofovir, lamivudine, and dolutegravir (TLD) in sub-Saharan Africa. The primary outcome of interest will be viral suppression to <50 copies/mL at 48 weeks using the FDA snapshot definition. The study will be conducted in Uganda and South Africa.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 15 years and above

  • Enrolled in HIV care at one of the study clinics

  • History of two HIV-1 RNA viral load measurements >1,000 copies/mL while on TLD

  • On TLD for at least 12 months

  • Lives within 100 kilometers of study clinic

  • Pregnant women are eligible for enrollment.

Exclusion

Exclusion Criteria:

  • Plans to transfer out of the clinic within the next 48 weeks

  • Plans to move out of the study catchment area within the next 48 weeks

  • As determined by chart review, we will exclude those with known virologic failure onprotease inhibitors or exposure to integrase strand transfer inhibitors other thandolutegravir.

Study Design

Total Participants: 648
Treatment Group(s): 4
Primary Treatment: Immediate Switch
Phase:
Study Start date:
February 07, 2024
Estimated Completion Date:
May 01, 2027

Study Description

The RESOLVE trial is an open, parallel arm, randomized clinical trial which will be conducted at public-sector HIV clinics in Uganda and South Africa. We will enroll individuals with HIV age 15 and above who have had two HIV-1 RNA viral load results >1,000 copies/mL while on TLD and who have been on TLD for at least 12 months. Participants will be randomized using an equal allocation ratio of 1:1:1 across three study arms: a) Standard of Care (regimen guided by genotypic resistance tests and care as per guidelines in Uganda; and with regimen selection and possible genotypic resistance testing (GRT) and care as per guidelines in South Africa), 2) Individualized Care with regimen choice based on results of genotypic resistance tests and urine tenofovir adherence assays, or 3) Immediate Switch to PI-based second-line ART. Randomization will be stratified by clinic, prior exposure to non-nucleoside reverse transcriptase inhibitors, and virologic failure history. We will follow participants for one year with study visits at enrollment, Week 24, and Week 48. The primary outcome of interest will be viral suppression to <50 copies/mL at 48 weeks using the FDA snapshot definition.

Connect with a study center

  • RK Khan Hospital Clinic

    Durban,
    South Africa

    Active - Recruiting

  • Mbarara City Clinic

    Mbarara,
    Uganda

    Active - Recruiting

  • Mbarara Regional Referral Hospital Immune Suppression Syndrome Clinic

    Mbarara,
    Uganda

    Active - Recruiting

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