Cefiderocol Plasma Concentrations in Patients Receiving Renal Replacement Therapy

Inclusion Criteria:

1. Age 18 years or older;

2. Receiving CRRT including CVVH, CVVHD, and CVVHDF support.

Exclusion Criteria:

1. Females who are pregnant or breast-feeding;

2. History of any moderate or severe hypersensitivity or allergic reaction to any β-lactam antibiotic (a history of mild rash to a cephalosporin followed byuneventful re-exposure is not a contraindication);

3. A hemoglobin less than 8 gm/dl at baseline;

4. Acute liver injury, defined as aspartate aminotransferase (AST) or alanineaminotransferase (ALT) > 5 times the upper limit of normal, or AST or ALT > 3 timesthe upper limit of normal with an associated total bilirubin > 2 times upper limitof normal;

5. Any rapidly-progressing disease or immediately life-threatening illness (defined asimminent death within 48 hours in the opinion of the investigator);

6. Any condition or circumstance that, in the opinion of the investigator, wouldcompromise the safety of the patient or the quality of study data.