Study Evaluating the Safety and Efficacy of AR-15512 (COMET-3)

Key Inclusion Criteria:

• Signs and symptoms of dry eye disease (DED) at the Screening and Baseline visits;

• Corrected visual acuity of +0.70 logarithm Minimum angle of resolution (LogMAR) orbetter in both eyes at Screening and Baseline visits;

• Other protocol-specified inclusion criteria may apply.

Key Exclusion Criteria:

• History or presence of any ocular disorder or condition (other than DED) in eithereye that would, in the opinion of the investigator, likely interfere with theinterpretation of the study results or subject safety;

• Regular use of lid hygiene within 14 days prior to the Screening visit or anyplanned use during the study;

• Use of artificial tears within 2 hours prior to the Screening visit or anticipateduse during the study;

• Medication use as specified in the protocol;

• History or presence of significant systemic disease;

• Other protocol-specified exclusion criteria may apply.