Screening for Abdominal Aortic Aneurysm and Popliteal Artery Aneurysm

Last updated: March 11, 2024
Sponsor: Centre Hospitalier Universitaire Vaudois
Overall Status: Active - Recruiting

Phase

N/A

Condition

Aneurysm

Heart Disease

Cardiovascular Disease

Treatment

N/A

Clinical Study ID

NCT05360108
DAAP-PR study
  • Ages 55-85
  • All Genders

Study Summary

Observational, prospective, cohort study to evaluate, by an opportunistic screening program based on vascular ultrasound, the prevalence and characteristics of Abdominal Aortic Aneurysm (AAA) and Popliteal Artery Aneurysm (PAA) in a female population as well as the prevalence and characteristics of PAA in male population.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Women aged ≥65 years who are current smokers
  • Men aged ≥65 years
  • Women or Men aged ≥55 years with family history (first-degree relatives) for AbdominalAortic Aneurysm (AAA) or popliteal artery aneurysm (PAA)

Exclusion

Exclusion Criteria:

  • Patient with known diagnosis of AAA or PAA
  • Patient already operated for AAA or PAA
  • AAA/PAA screening or arterial assessment of lower limbs within the last 12 months
  • Inability to understand and/or sign study consent
  • Inability to access follow-up controls

Study Design

Total Participants: 1000
Study Start date:
June 01, 2020
Estimated Completion Date:
June 30, 2028

Study Description

Abdominal aortic aneurysm (AAA) remains a highly topical issue given the potentially dramatic consequences associated with its rupture. In men, the prevalence of AAA is declining, probably due to improved management of risk factors. However, the most recent studies and international recommendations have reaffirmed that screening for AAA in men is still important and cost-effective. In contrast, data regarding the risk and characteristics of AAA in women are very limited and outdated. For this reason, the recommendations are contrasting and not univocal. About 35% of patients with AAA have a second aneurysm more distally. Popliteal artery aneurysm (PAA) is the most common. Like AAA, PAA is often asymptomatic and its main complication is thrombotic occlusion resulting in acute/chronic ischemia of the affected limb and a high prevalence of permanent sequelae (mainly amputation). Data on epidemiology and risk factors of PAA are very limited in men and absent in women. In addition, the benefit of PAA screening has never been assessed so far.

The aim of this study is to evaluate, by an opportunistic screening program based on vascular ultrasound, the prevalence and characteristics of AAA and PAA in a female population as well as the prevalence and characteristics of PAA in male population. The project represents the first screening program for popliteal aneurysm. Finally, the results will allow us to better assess need for and modalities of a screening program.

Connect with a study center

  • Ospedale di Castelfranco Veneto, UOC Angiologia

    Castelfranco Veneto, TV I-31033
    Italy

    Active - Recruiting

  • Centre Hospitalier Universitaire Vaudois (CHUV), Service d'Angiologie

    Lausanne, VD 1011
    Switzerland

    Active - Recruiting

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