Delta Q Value to Discriminate Detrusor Underactivity From Bladder Outlet Obstruction

Last updated: April 29, 2022
Sponsor: Ain Shams University
Overall Status: Completed

Phase

2/3

Condition

Enuresis

Genitourinary Prolapse

Dyskinesias

Treatment

N/A

Clinical Study ID

NCT05359484
K22/2019
  • Ages > 50
  • Male

Study Summary

To determine the significance of delta Q value (Qmax - Qave) in discrimination between BOO and DU, to avoid invasive studies (pressure flow studies (PFSs)) and replace them with noninvasive study (uroflowmetry).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • male patients aged over 50 years complaining of voiding symptoms
  • International Prostatic Symptom Score (IPSS) 8 points or more,
  • serum prostate-specific antigen (PSA) below 4 ng/ml
  • no hematuria or pyuria.

Exclusion

Exclusion Criteria:

  • Patients who were unable to complete the voiding study were deemed not eligible toparticipate in this review.
  • patients with neurological causes of voiding dysfunction
  • history of urinary tract abnormalities/lithiasis, lower urinary tract surgeries,urinary tract malignancy.
  • acute UTI were excluded.

Study Design

Total Participants: 238
Study Start date:
January 01, 2019
Estimated Completion Date:
May 01, 2021

Study Description

lower urinary tract symptoms (LUTS) in old male patients are usually secondary to prostatic hyperplasia. However, it is becoming clear nowadays that prostatic enlargement is not always the cause of male LUTS, and other factors could cause male LUTS in the presence of benign prostate enlargement (BPE).

Two clinical situations are common in elderly patients like Bladder Outlet Obstruction (BOO) and Detrusor underactivity (DU) they affect the voiding phase in elderly men markedly.

To distinguish one from another may be challenging and could be only done by urodynamic study (UDS), which is the gold standard for diagnosis.

A urodynamic study is an invasive procedure, with side effects of pain and urinary tract infection, and the need for special equipment and expertise has limited its widespread use and made it very stressful for the patients.

On the other hand, Uroflowmetry is a non-invasive procedure that could be used in patients' assessments. A term of Delta Q is being used that focuses on the difference between (Qmax) and (Q-average). The hypothesis is that Delta Q would be lower in Detrusor underactivity because of the undermined detrusor function decreasing both average and maximum urine flow rate, but it is higher in BOO, which has normal detrusor contraction during the voiding phase.

Based on the concept uroflow can be used to replace urodynamic studies to differentiate between these 2 entities and hence to determine the proper management plan and to be a prognostic factor before surgical intervention.

Connect with a study center

  • Ahmed Maher

    Cairo, القاهرة 11757
    Egypt

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.