A Study to Evaluate the Long-term Safety of Inclacumab Administered to Participants With Sickle Cell Disease

Inclusion Criteria:

Participants who meet all the following criteria will be eligible for study enrollment:

1. Male or female participant with SCD who participated and received study drug in aGBT-Sponsored inclacumab clinical study.

2. Participant has completed the originating inclacumab study within 30 calendar daysof the Day 1 Visit. Participants who discontinued study drug in the originatingstudy due to a non-study drug-related AE, but who remained on study, may be eligiblefor treatment in this study provided the AE does not pose a risk for treatment withinclacumab.

3. Female participants of childbearing potential are required to have a negative urinepregnancy test prior to dosing on Day 1. Note: Female participants who become of childbearing potential during the study mustbe willing to have a negative urine pregnancy test to remain in the study.

4. If sexually active, female participants of childbearing potential must consistentlyuse highly effective methods of contraception consistently throughout the study andfor at least 165 days after the last dose of study drug. If sexually active, maleparticipants must use barrier methods of contraception until 165 days after the lastdose of study drug.

5. Participant has provided written informed consent/assent. For underage participants,both the consent of the participant's legal representative or legal guardian and theparticipant's assent (where applicable) must be obtained based on local requirement.

Exclusion Criteria:

Participants meeting any of the following exclusion criteria will not be eligible for study enrollment:

1. Female participant who is breastfeeding or pregnant.

2. Participant had an infusions-related reaction (IRR) in the originating inclacumabclinical study.

3. Participant withdrew consent from the originating inclacumab clinical study.

4. Participant was lost to follow-up from the originating inclacumab clinical study.

5. Participant has any medical, psychological, safety, or behavioral conditions that,in the opinion of the Investigator, may confound safety interpretation, interferewith compliance, or preclude informed consent.