Non-invasive Vagal Stimulation for Frequent Premature Ventricular Complexes

Inclusion Criteria:

• Adults (>18 years old) but < 80 years of age

• Symptomatic PVCs or asymptomatic PVCs with a burden > 5%

• Intolerant to or unwilling to take beta blockers and nondihydropyridine calciumchannel blockers or beta blockers and nondihydropyridine calcium channel blockershave proved ineffective

Exclusion Criteria:

• Ischemic cardiomyopathy with LVEF < 40%

• Severe heart failure (New York Heart Association Class III, or IV) or valve disease

• Sustained ventricular tachycardia

• Structural heart disease or myocardial scar

• Pregnancy or nursing

• Patients with known thyroid issues, on renal dialysis.

• Patients with prolonged first-degree block, high degree AV block (2nd or 3rddegree), bivascular block and documented sick sinus syndrome

• Hypotension due to autonomic dysfunction

• Patients with cardiac implantable electronic device (ICD or PPM) , hearing aidimplants or any implanted metallic or electronic device

• Patients who have had prior cervical vagotomy

• Patients with skin on the tragus that is broken or cracked

• Patients with a history of baseline cardiac disease or atheroscleroticcardiovascular disease, including congestive heart failure (CHF), known severecoronary artery disease or recent myocardial infarction (within 5 years) andpatients diagnosed with narrowing of the arteries (carotid atherosclerosis)