Improving Communication and Adherence in Black Breast Cancer Survivors (Sisters Informing Sisters)

Last updated: October 28, 2025
Sponsor: Virginia Commonwealth University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cancer

Breast Cancer

Treatment

SIS TALK Back Intervention

Clinical Study ID

NCT05334732
MCC-19-15740
HM20016396
  • Ages > 18
  • Female

Study Summary

The purpose of this study is to test an evidence-based intervention designed to increase adherence to systemic therapy in Black women compared to enhanced usual care.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Self-identify as Black

  • Newly diagnosed (~4 weeks post-definitive surgery and prior to initiation of adjuvant chemotherapy or endocrine therapy) patients (stage I-III)

  • Eligible for chemotherapy or endocrine therapy according to NCCN guidelines, but have not initiated systemic therapy

  • Ability to read and speak English

  • Ability to provide meaningful consent as determined by trained study personnel and/or a member of the patient's care team

  • No prior cancer treatment (other than skin cancer) in the two years preceding enrollment

  • Physicians Must be a license doctor of study patient(s)

  • Ability to speak English

Study Design

Total Participants: 250
Treatment Group(s): 1
Primary Treatment: SIS TALK Back Intervention
Phase:
Study Start date:
March 01, 2021
Estimated Completion Date:
February 28, 2026

Study Description

Black women continue to experience worse breast cancer outcomes, which may be due to inadequate adherence to systemic therapies that can be improved via patient-centered communication. We developed and piloted the Sisters Informing SistersSM (SIS) intervention (survivor-led skill-building sessions and culturally tailored materials to activate Black breast cancer survivors in their medical encounters) and obtained promising findings. This project will compare in a two-arm RCT the impact of SIS vs. enhanced usual care (treatment recommendation summary form) on patient-centered communication and systemic treatment adherence; SIS tools may be integrated within existing clinical and support services.

Connect with a study center

  • Medstar Georgetown University Hospital

    Washington, District of Columbia 20007
    United States

    Site Not Available

  • MedStar Washington Hospital Center

    Washington D.C. 4140963, District of Columbia 4138106 20010
    United States

    Active - Recruiting

  • Medstar Georgetown University Hospital

    Washington D.C. 4140963, District of Columbia 4138106 20007
    United States

    Active - Recruiting

  • Massey Cancer Center

    Richmond, Virginia 23298
    United States

    Site Not Available

  • Massey Cancer Center

    Richmond 4781708, Virginia 6254928 23298
    United States

    Active - Recruiting

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