Collagenase Chemonucleolysis vs Percutaneous Endoscopic Lumbar Discectomy (PELD) for Lumbar Disc Herniation

Last updated: March 9, 2023
Sponsor: Shenzhen People's Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Radiculopathy

Hernia

Spondylolisthesis

Treatment

N/A

Clinical Study ID

NCT05330806
ShenzhenPH spine wang05
  • Ages 18-70
  • All Genders

Study Summary

Lumbar disc herniation compressed the nerve cause pain, numbness, weak legs called sciatica, which seriously decrease the quality of life and work efficiency. Both collagenase chemonucleolysis(CCNL) and percutaneous endoscopic lumbar discectomy (PELD) was effective to treat lumbar disc herniation(LDH) requires surgery. whether functional clinical outcomes of CCNL vs PELD effect on LDH was superior, and no study provided convincing evidence.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • at least six weeks of excessive radiating leg pain with no tendency for any clinicalimprovement despite conservative therapy
  • have a nerve root compression by a lumbar disc herniation proven by magnetic resonanceimaging

Exclusion

Exclusion Criteria:

  • previous surgery at the same or adjacent disc level;
  • isthmic or degenerative spondylolisthesis
  • pregnancy
  • severe comorbid medical or psychiatric disorder (American Society ofAnesthesiologists' classification >2);
  • severe caudal or cranial sequestration of disc fragments, defined as sequestrationtowards more than half of the adjacent vertebra;
  • contraindication for surgery

Study Design

Total Participants: 140
Study Start date:
January 15, 2021
Estimated Completion Date:
June 28, 2023

Study Description

Lumbar disc herniation (LDH) is a common disease with an incidence of 1%-3%, usually manifested as low back pain radiating to the lower extremities, which seriously affects patients' quality of life. Collagen hydrolysis was effective in treating LDH, it makes the protrusion smaller or disappeared, relieving or resolving the compression of nerve root by the protrusion.Percutaneous endoscopic lumbar discectomy (PELD) is a less invasive techniques to treat LDH. However, the outcomes of collagen hydrolysis vs PELD effect was still unknown.

Connect with a study center

  • ShenzhenPH

    Shenzhen, Guangdong 518000
    China

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.