Comparison of Triggers in Double Ovarian Stimulation (DuoStim).

Last updated: April 4, 2022
Sponsor: Instituto Bernabeu
Overall Status: Active - Recruiting

Phase

4

Condition

In Vitro Fertilization

Treatment

N/A

Clinical Study ID

NCT05321511
IB-0121
  • Ages 28-43
  • Female
  • Accepts Healthy Volunteers

Study Summary

This study aims to investigate the efficacy of 3 different trigggers used for final maturation in the second ovarian stimulation in double stimulation protocol (aGnRH and hCG-rec vs. aGnRH only vs. hCG-rec only). The main objective is to compare the number of all retrieved oocytes and mature oocytes in patients predicted to be low ovarian responders.

This is a controlled randomized clinical study where 165 patients will be recruited.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • BMI below 32
  • Presence of both ovaries
  • Indication for ovarian stimulation under Double Stimulation protocol (Duo Stim)
  • Meeting the criteria for Duo Stim
  • Medical history, history and physical examination without alterations
  • AMH and AFV results in accordnace to Poseidon classification group 3 or 4 no more than 6 months prior to signing the consent form
  • Ability to participate and comply with the study protocol.
  • To have given written consent
  • Normal karyotype and fragile X.

Exclusion

Exclusion Criteria:

  • Non-compliance with instructions and/or non-formalization of consents or legalrequirements for IVF.
  • Concurrent participation in another study

Study Design

Total Participants: 165
Study Start date:
March 03, 2022
Estimated Completion Date:
March 31, 2023

Connect with a study center

  • Instituto Bernabeu

    Palma De Mallorca, Mallorca 07006
    Spain

    Active - Recruiting

  • Instituto Bernabeu

    Albacete, 02005
    Spain

    Active - Recruiting

  • Instituto Bernabeu

    Alicante, 03016
    Spain

    Active - Recruiting

  • Instituto Bernabeu

    Madrid, 28001
    Spain

    Active - Recruiting

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