Observational Study of the Efficacy and Safety of Anlotinib Combined With Penpulimab in Elderly Lung Cancer Patients

Inclusion Criteria:

• At least 65 years old;
• Non-small cell lung cancer with locally advanced, recurrent or metastasis, whichconfirmed by histologically or cytologically (except sputum cytology) and evaluated asIIIB-IV stage, who are unresectable or unable to undergo radical radiotherapy orrefuse radical radiotherapy. (If multiple tumor components are mixed, it should beclassified according to their predominant cell type);
• Participants are required to have one measurable disease per RECIST 1.1;
• Unsuitable or unwilling to receive radical treatment methods (such as radicalchemoradiotherapy and/or surgery) and have not received prior systemic therapy;
• ECOG performance status of 0 to 2; The expected survival is more than 3 months;
• Adequate organ and marrow function defined as follows:
• Hemoglobin (HB) ≥90 g/L (no blood transfusion within 28 days);
• Absolute neutrophil count (ANC) ≥1.5×109/L;
• Platelet count (PLT) ≥ 100×109/L;
• Aspartate Transaminase (AST) ≤ 1.5 x upper limit of normal (ULN);
• Alaninetransaminase (ALT) ≤ 1.5 x ULN (ALT and AST ≤ 5 x ULN if liver metastasesare present);
• Alkaline phosphatase (ALP) ≤ 1.5 x ULN;
• Albumin (ALB) ≥ 30g/L;
• Creatinine ≤1.5 x ULN or Creatinine Clearance (CCr) ≥ 60 ml/min;
• International normalized ratio (INR) ≤ 1.5 x ULN;
• Partial thromboplastin time (APTT) ≤ 1.5 x ULN;
• Prothrombin time (PT) ≤ 1.5 x ULN ;
• Thyrotropic hormone (TSH) ≤ ULN (When TSH value is abnormal, T3 and T4 levels isnormal, which can be enrolled);
• Urine protein < (++), or 24-hour urine protein amount < 1.0 g ;
• Patients must have adequate cardiac function, defined as: Left ventricular ejection fraction (LVEF) > 50% as determined by cardiac echocardiogram.

-Patients enrolled in this study voluntarily and signed an informed consent with a goodcompliance.

Exclusion Criteria:

• Participants who have active infection;
• Patients with known immunodeficiency diseases (e.g. psoriasis, active arthritis,immune nephropathy, HIV, etc);
• Participants with no measurable disease;
• Patients with cancerous meningitis and spinal cord compression;
• Participants with active central nervous system (CNS) metastases (clinically stableand maintained for at least 2 weeks after adequate treatment of CNS metastases and donot require treatment such as glucocorticoids and dehydrating drugs are eligible forenrollment);
• Previously treated with chemotherapy drugs (except neoadjuvant therapy) / targeteddrugs / immunotherapy;
• Participants who were confirmed severe abnormalities of gastrointestinal function (e.g. inability to take oral medications, uncontrollable nausea or vomiting, historyof major gastrointestinal resection, untreated recurrent diarrhea, untreated gastricdisease requiring long-term acid-suppressing PPI-like medications, Crohn's disease,ulcerative colitis);
• Patients with central squamous lung cancer on imaging;
• Patients who had an arterial/venous thrombotic event within 6 months, such ascerebrovascular accident (temporary ischemic attack is excluded), deep vein thrombosisand pulmonary embolism;
• Patients whose imaging shows that the tumor has invaded a significant vessel or have ahigh risk of fatal hemorrhage due to tumor invasion of a significant vessel during thefollow-up study judged by the investigator; or who have bleeding tendencies (e.g.,active peptic ulcer) or receiving thrombolytic or anticoagulant therapy such aswarfarin, heparin, or their analogs;
• Patients who had antineoplastic therapy against other malignancies, includingradiotherapy, chemotherapy, immunotherapy and herbal medicine (except previouslyeradicated malignancies without recurrent metastases for ≥ 5 years);
• Patients with uncontrollable pleural effusion, pericardial effusion or ascitesrequiring repeated drainage (except patients who do not require drainage of effusionor whose effusion does not increase significantly after 3 days of cessation ofdrainage);
• Patients who have used immunosuppressive drugs within 4 weeks prior to the studytreatment, except for topical glucocorticoids by nasal spray, inhalation or otherroutes or physiologic doses of systemic glucocorticoids (no more than 10 mg/day ofprednisone or equivalent doses of other glucocorticoids);
• Patients who have known or suspected active autoimmune disease (congenital oracquired), such as interstitial pneumonia, uveitis, enterocolitis, hepatitis,pituitary inflammation, vasculitis, nephritis, thyroiditis, etc. (Patients withvitiligo or asthma that has completely resolved in childhood and does not require anyintervention in adulthood may be enrolled; Patients with type I diabetes with goodinsulin control may be enrolled);
• Patients who have known allogeneic organ transplantation (except cornealtransplantation) or allogeneic hematopoietic stem cell transplantation;
• Anticipants who have hypersensitivity to any component of anlotinib and monoclonalantibodies;
• Anticipants who have active interstitial lung disease requiring treatment;
• Anticipants who have a history of psychotropic substance abuse and are unable toabstain or have a psychiatric disorder;
• Anticipants who have participated in another anti-tumor clinical trial within fourweeks;
• Anticipants who administered anti-infective vaccines (e.g., influenza virus vaccine,human papillomavirus vaccine) within 4 weeks prior to study therapy; During thetreatment period, in addition to inactive vaccines, other vaccines are prohibited;
• Anticipants who have undergone major surgery (except for diagnostic purposes) within 4weeks (28 days) prior to the administration of the study;
• Patients who are not suitable for enrollment in the judgment of the investigator.