Exercise Fatiguability in Older Adults: The Protective Effects of Dietary Nitrate Supplementation

Last updated: August 22, 2022
Sponsor: Marquette University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Aging

Treatment

N/A

Clinical Study ID

NCT05313490
HR-4040
  • Ages 60-90
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Vascular and skeletal muscle function decline with age and are associated with decreased nitric oxide (NO) bioavailability. Dietary nitrate supplementation in the form of beet root juice increases NO bioavailability and improves exercise tolerance in younger adults, yet its effects on fatigability in older adults are largely unknown. The proposed research will investigate the impact of increased NO bioavailability on vascular function, skeletal muscle bioenergetics, and fatigability in older (≥65 yrs) men and women.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Healthy men and women ≥ 60 years old

Exclusion

Exclusion Criteria:

  1. body mass index ≥40 kg/m2;
  2. type 1 or type 2 diabetes or HbA1c >6.5%
  3. uncontrolled hypertension;
  4. active cancer, cancer in remission, or having received treatment for any form ofcancer in the previous five years;
  5. coronary artery disease;
  6. cardiovascular disease (e.g., PAD, PVD);
  7. abnormal and untreated thyroid function;
  8. chronic and/or regular nonsteroidal anti-inflammatory drugs (NSAID) consumption,
  9. tobacco use (includes smoking);
  10. any condition that presents a limitation to exercise (e.g., severe arthritis, COPD,neuromuscular disorder, moderate or severe cognitive impairment, Alzheimer's Disease,severe untreated sleep apnea).

Study Design

Total Participants: 40
Study Start date:
May 01, 2022
Estimated Completion Date:
December 31, 2023

Connect with a study center

  • Marquette University

    Milwaukee, Wisconsin 53233
    United States

    Active - Recruiting

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