Physio-Anatomy Clinical Data Collection Study

Inclusion Criteria:

• Patients >18 years of age.

• Patients provide written informed consent.

• Clinical presentation consistent with suspected coronary disease.

• Patients who are candidates for PCI and scheduled for coronary diagnostics in thecardiac catheter lab with the intent to perform a physiological assessment for denovo lesions with stenosis, if clinically indicated.

Exclusion Criteria:

• Presence of acute ST Elevation Myocardial Infarction (STEMI) at the time of the cathlab procedure.

• Contraindication for FFR examination or administration of vasodilators.

• Bacteremia or sepsis.

• Major coagulation system abnormalities.

• Severe hemodynamic instability or shock.

• Heart Failure NYHA Class IV.

• Severe valvular heart disease.

• Prior heart transplant.

• Acute renal failure based on diagnostic practice of the treating physician at timeof screening.

• Patient is pregnant.

• Patient is currently enrolled in another clinical study that may impact the resultsof this study.

• Patient has other co-morbid condition(s) that, in the opinion of the Investigator,could limit their