EyeConic: Qualification for Cone-Optogenetics

Last updated: February 6, 2025
Sponsor: University Hospital, Basel, Switzerland
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

OCT

Optical coherence tomography (OCT)

Clinical Study ID

NCT05294978
IOB_EyeConic_2021
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.

Eligibility Criteria

Inclusion

Inclusion Criteria (patients):

  • Diagnosis of generalized IRD

  • Low vision as defined as visual acuity worse or equal to 0.05 (or 20/400) in the study eye

  • Availability of macular optical coherence tomography (OCT)

Inclusion Criteria (controls):

  • Normal ophthalmic findings

  • Availability of macular optical coherence tomography (OCT)

Exclusion Criteria (all):

  • Other eye diseases with a significant effect on vision or retinal structure

  • Extraocular disease affecting retinal structure such as neurodegenerative diseases

Study Design

Total Participants: 1000
Treatment Group(s): 2
Primary Treatment: OCT
Phase:
Study Start date:
July 01, 2021
Estimated Completion Date:
December 31, 2026

Study Description

In a subset of patients with inherited retinal dystrophies (IRDs), cones lose their light-sensitive outer segments but remain alive in a dormant stage. This creates an opportunity to resensitize them through targeted optogenetic tools. However, the true proportion of low vision patients harboring dormant, non-functional cones, is currently unknown. The worldwide multicenter retrospective study (EyeConic) aims to estimate the proportion of low vision patients with remaining cone cell bodies for the first time.

Connect with a study center

  • Beijing Institute of Ophthalmology

    Beijing,
    China

    Active - Recruiting

  • Universitätsklinikum Tübingen Augenklinik

    Tübingen,
    Germany

    Active - Recruiting

  • Semmelweis University, Department of Ophthalmology

    Budapest,
    Hungary

    Active - Recruiting

  • Oculista Ospedale Parma

    Parma,
    Italy

    Active - Recruiting

  • University Hospital Basel, Eye Clinic

    Basel, 4031
    Switzerland

    Active - Recruiting

  • Moorfields Eye Hospital

    London,
    United Kingdom

    Active - Recruiting

  • University of California San Francisco, Department of Ophthalmology

    San Francisco, California 94158
    United States

    Active - Recruiting

  • Bascom Palmer Eye Institute

    Miami, Florida 33136
    United States

    Active - Recruiting

  • University of Pittsburgh, Department of Ophthalmology

    Pittsburgh, Pennsylvania 15213
    United States

    Active - Recruiting

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