Autologous Regenerative Islet Transplantation for Insulin-dependent Diabetes

Inclusion Criteria:

• Insulin-dependent diabetes mellitus, the specific criteria are (1 of 4-6 issufficient).

1. Age: 18-70 years old;
2. History of diabetes mellitus >1 year;
3. Insulin-dependent and total daily insulin dose >20 units;
4. Poor blood glucose control despite intensive exogenous insulin therapy (or highblood glucose fluctuation, glycation >8% );
5. Frequent hypoglycemic episodes with unconsciousness; 6) Diabetic nephropathy,patients who need to receive kidney transplantation.

Exclusion Criteria:

• 1. Severe heart disease; 2) Severe mental disorders, poor compliance or alcohol abuse;

3. Active infection or with malignancy; 4) Weight greater than 25% of ideal weight; 5)Evidence of endogenous insulin secretion, such as type 2 diabetes; 6) Smoking; 7)During gestation or preparation for gestation.