Laryngeal Nerve Block for Chronic Cough

Last updated: March 14, 2022
Sponsor: Eastern Virginia Medical School
Overall Status: Active - Recruiting

Phase

4

Condition

Allergy (Pediatric)

Allergy

Allergies & Asthma

Treatment

N/A

Clinical Study ID

NCT05292677
14Jul2021
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to study the potential benefit of treating chronic neurogenic cough by blocking the nerve responsible for the disease with an injection of local anesthetic/steroid mixture versus a placebo.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 18 years and older
  • Previously or Newly Diagnosed Chronic Neurogenic Cough

Exclusion

Exclusion Criteria:

  • History of Laryngeal Surgery or External Beam Radiation
  • Current Smokers
  • Known Allergy or Sensitivity to Local Anesthetics
  • Uncontrolled Pulmonary, SinoNasal, or GastroIntestinal Pathology leading to RefractoryChronic Cough

Study Design

Total Participants: 40
Study Start date:
July 21, 2021
Estimated Completion Date:
June 25, 2023

Study Description

This study will be performed by asking participants to fill out multiple questionnaires on the symptoms of their cough, and undergo cough testing by inhaling an airway irritant and monitoring the number of coughs after inhalation of the irritant. Subjects would then undergo the treatment and have an injection of either local anesthetic/steroid mixture or a placebo (normal saline) around the nerve that gives feeling to the portion of the voice box responsible for chronic neurogenic cough. After the injection you will be asked to repeat the cough testing and questionnaires 30 minutes, 1 weeks, and at 6 weeks post injection. After the initial six weeks, patients will cross over and repeat the same process with the opposite treatment (either local anesthetic/steroid mixture or placebo) from their previous injection. The total time of participation is about 12 weeks and we hope to recruit 40 subjects.

Connect with a study center

  • Eastern Virginia Medical School Ear, Nose, and Throat Surgeons

    Norfolk, Virginia 23507
    United States

    Active - Recruiting

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