Repetitive Transcranial Magnetic Stimulation to People With Cannabis Use Disorder (SToP-C-rTMS x CUD)

Last updated: July 7, 2025
Sponsor: The University of Hong Kong
Overall Status: Completed

Phase

N/A

Condition

Substance Abuse

Treatment

Repetitive Transcranial Magnetic Stimulation

Clinical Study ID

NCT05292547
UW21-656
  • Ages 18-65
  • All Genders

Study Summary

This study is to explore if repetitive transcrinal magnetic stimulation (rTMS) with different stimulation schedules will be equally effective in reducing carving, frequency of cannabis use, and the severity of cannabis use disorder in participants suffering from cannabis use disorder (CUD).

The investigators assume the hypotheses as:

  1. Multiple rTMS sessions can reduce craving for cannabis, severity of CUD, frequency and amount of cannabis use.

  2. Different rTMS treatment schedules have differences in reducing the craving for cannabis and severity of CUD, and prolonging relapse of cannabis use.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Able to read and communicate in English and/or Chinese SToP-C-rTMS x CUD

  • Able to give informed consent

  • Using cannabis or marijuana as the primary psychoactive substance of abuse

  • Diagnosed with Cannabis Use Disorder according to the Diagnostic and StatisticalManual of Mental Disorders 5th Edition (DSM-5) by the Structured Clinical Interviewfor DSM-5 Disorders (SCID-5)

Exclusion

Exclusion Criteria:

  • Age <18 years old

  • Unable to read English or Chinese

  • Unable to give informed consent

  • Had been diagnosed with the following disorders, including neurodevelopmentaldisorders, DSM-5 defined substance use disorder greater than moderate in severity,and neurocognitive disorders

  • Contra-indicated to have rTMS, including subjects with electronic and/or magneticimplants (e.g. pacemaker, implantable cardioverter defibrillator [ICD], cerebralshunts, cochlear implant, etc.), with metallic or mechanic fragments (e.g., screws,plates, stents, clips, etc.), pregnant, with any known or history of neurologicalconditions including cerebral vascular accidents, epilepsy, brain tumor or spaceoccupying lesion, poorly controlled or unstable diabetes mellitus, and receivingunstable dose(s) of antipsychotics, antidepressants, benzodiazepines and/oranticonvulsants in the past 6 months

Study Design

Total Participants: 20
Treatment Group(s): 1
Primary Treatment: Repetitive Transcranial Magnetic Stimulation
Phase:
Study Start date:
September 01, 2022
Estimated Completion Date:
March 31, 2025

Connect with a study center

  • Queen Mary Hospital

    Hong Kong, 000000
    Hong Kong

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.