Candida Antigen and Bivalent HPV Vaccine in the Treatment of Multiple Warts

Last updated: June 9, 2025
Sponsor: Zagazig University
Overall Status: Active - Recruiting

Phase

2

Condition

Warts

Treatment

Candida antigen vaccine

Bivalent HPV vaccine

Clinical Study ID

NCT05291845
C.ag-vs-B.HPV.V
  • Ages > 9
  • All Genders

Study Summary

To follow up the efficacy and safety of Candida antigen, bivalent HPV vaccine in treatment of common warts either mono or combined intralesional therapy

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • patients with multiple, recalcitrant, or non-recalcitrant common warts of differentsites, sizes, duration, and with or without distant lesions will be enrolled in thestudy

Exclusion

Exclusion Criteria:

  • Pregnant female. Hypersensitivity to Candida antigen or bivalent HPV vaccine

Study Design

Total Participants: 162
Treatment Group(s): 2
Primary Treatment: Candida antigen vaccine
Phase: 2
Study Start date:
April 03, 2022
Estimated Completion Date:
December 06, 2025

Study Description

  • Group A: 54 patients will be treated with Candida antigen. All patients will be directly injected with Candida antigen into the largest wart using an insulin syringe. Injections will be done at 2-week intervals until complete clearance will be achieved or for a maximum of five treatment sessions.

  • Group B: 54 patients will be treated with bivalent HPV vaccine solution intralesional into the largest wart using an insulin syringe. Injections will be done at 2-week intervals until complete clearance will be achieved or for a maximum of five treatment sessions.

  • Group C: 54 patients will be treated with both agents intralesionally into the largest wart using an insulin syringe at 2-week intervals until complete clearance will be achieved or for a maximum of five treatment sessions.

it is thought that candida antigen act through a cell-mediated immune response and bivalent HPV vaccine act mainly through humoral immunity, so we want to study their effect as single or mixed agents

Connect with a study center

  • Reham Essam

    Zagazig, Al Sharqia 2543
    Egypt

    Active - Recruiting

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