Phase
Condition
Neurofibromatosis
Cancer/tumors
Astrocytoma
Treatment
Carboplatin
Recombinant human endostatin
Vincristine
Clinical Study ID
Ages 3-21 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Age ≥ 3months and ≤21years;
Patients with optic pathway gliomas diagnosed by histopathology or characteristicbrain MRI and clinical features;
Measurable lesions, surgical resection degree < 95% or postoperative residual tumor ≥1.5cm^2;
KPS score ≥50 (age >12 years) or Lansky score ≥50 (age ≤12 years);
Clinical symptoms such as decreased visual acuity, visual field defect, optic discedema, exophthalmia, increased intracranial pressure, diencephalic syndrome, etc;
No dysfunction of major organs.
Exclusion
Exclusion Criteria:
MRI examination is not available.
Failing to comply with the visual examination.
H3K27 mutations, even histopathological grade 1/2.
Receiving any other investigational agent.
History of allergic reactions attributed to compounds of similar chemical orbiologic composition to the drugs used in this study.
Patients who have received organ transplants.
Patients infected with HIV or treponema pallidum.
Suffering from serious cardiovascular disease;T wave inversion or elevation or STsegment changes.
Patients who had coagulation disorder and were being treated with thrombolytic oranticoagulant drugs. Patients with significant clinical bleeding symptoms or clearbleeding tendency occurred within 3 months before enrollment, such asgastrointestinal bleeding, hemorrhagic gastric ulcer, gastrointestinal perforation,baseline fecal occult blood ++ or above, intratumoral or intracranial bleeding, orvasculitis, etc. Arteriovenous thrombosis events (such as cerebrovascular accident (including transient ischemic attack, cerebral hemorrhage and cerebral infarction),deep vein thrombosis and pulmonary embolism) occurred within 6 months beforeenrollment.
Pregnant or breastfeeding.
Other conditions considered inappropriate by the researcher for inclusion.
Study Design
Connect with a study center
Capital Medical University Sanbo Brain Hospital
Beijing,
ChinaActive - Recruiting
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