Dextromethorphan for Treatment of Postoperative Pain

Last updated: December 10, 2024
Sponsor: Nathanael Heckmann
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Placebo

Dextromethorphan Hydrobromide

Clinical Study ID

NCT05278494
HS-22-00191
  • Ages > 18
  • All Genders

Study Summary

A Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Perioperative Dextromethorphan compared to Placebo for the Treatment of Postoperative Pain

Eligibility Criteria

Inclusion

Main Inclusion Criteria:

  • Patients Age ≥18 planning to undergo total knee arthroplasty

  • ASA classes I - III

Exclusion

Main Exclusion Criteria:

  • BMI ≥ 35

  • History opioid abuse

  • History of intractable vomiting after previous surgery

Study Design

Total Participants: 160
Treatment Group(s): 2
Primary Treatment: Placebo
Phase:
Study Start date:
September 15, 2022
Estimated Completion Date:
December 31, 2026

Study Description

There is extensive preclinical evidence that dextromethorphan has an analgesic effect in patients with pain of traumatic origin. The primary objective is to of this study is to evaluate the efficacy of perioperative dextromethorphan compared to placebo for postoperative pain in patients undergoing total knee arthroplasty (TKA).

This is a single-institution, multi-dose, randomized, placebo-controlled, trial to evaluate the efficacy of perioperative dextromethorphan compared to placebo for postoperative pain in patients undergoing TKA. Male and/or female patients will be randomized to either dextromethorphan treatment group (n = 80) or placebo group (n= 80).

Patients will receive 60 mg oral dextromethorphan (or matching placebo) preoperatively, as well as 30 mg 8- and 16-hours postoperatively.

Connect with a study center

  • Keck School of Medicine of USC

    Los Angeles, California 90033
    United States

    Active - Recruiting

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