Efficacy, Safety and Pharmacokinetics Study of CPL500036 (PDE10A Inhibitor) in Patients With Schizophrenia

Inclusion Criteria:

1. The patient has a primary diagnosis of schizophrenia confirmed by clinical interview [SCID-5-CT].

2. Male or female patient aged 18 to 65, inclusive, at Screening.

3. The patient's with exacerbation of psychotic symptoms

4. The patient has a score of 5 or higher in 3 or more items of the following PANSSitems at Screening and Baseline

5. The patient has a PANSS Total Score of 80 or higher during Screening and on Baseline

6. The patient of childbearing potential willing to use acceptable forms ofcontraception.

7. The patient has a score in CGI-S scale of 4 or greater at Screening and on Baseline

8. The patient is able to and agrees to remain off prior antipsychotic medication andall excluded medications as outlined in the protocol for the duration of theTreatment Period.

9. The patient is able to sign informed consent after receiving information about thetrial and has the ability and willingness to comply with the requirements andrestrictions of the study protocol.

Exclusion Criteria:

1. The patient has a decrease in the PANSS Total Score at Baseline compared with theTotal Score at Screening.

2. Patient who recently participated in another interventional clinical study with anInvestigational Medicinal Product.

3. The patient has uncontrolled abnormality which may impact the ability of the patientto participate or potentially confound the study results.

4. The patient has a history of severe head injury, traumatic brain injury, myocardialinfarction or stroke.

5. The patient has a moderate or severe substance use disorder for alcohol or othersubstances of abuse except nicotine or caffeine.

6. The patient is pregnant or lactating or intending to become pregnant or intending todonate ova.

7. The patient has a history of or known personality disorder or other psychiatricdisorder that, in the opinion of the Investigator, would interfere withparticipation in the study.

8. The patient is considered by the Investigator to be at imminent risk of suicide orinjury to self or others.

9. The patient has chronic movement disorder that may interfere with the interpretationof study results.

10. The patient has any existing or previous history of cancer or has newly diagnoseddiabetes.

11. The patient has long QT syndrome or is under treatment with antiarrhythmic drugs.

12. The patient is considered to be treatment resistant. .

13. The patient has received electroconvulsive therapy.

14. The patient has any laboratory values outside the normal range that are consideredby the Investigator to be clinically significant at Screening.