Neuroplasticity After Proprioceptive Rehabiliation

Last updated: December 20, 2024
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Overall Status: Active - Recruiting

Phase

N/A

Condition

Stroke

Neurologic Disorders

Cerebral Ischemia

Treatment

Vibrations

Clinical Study ID

NCT05277519
C20-11
2021-A00822-39
  • Ages 18-70
  • All Genders

Study Summary

Sequences of muscle tendon vibrations allow to reproduce the sensory feedback during movement like locomotion and kinaesthesia. It is known that such a treatment promotes motor recovery after stroke assuming that it enhances neuroplasticity. The aim of the research is to study the activity in cerebrospinal circuitry to evaluate the neuroplastic changes during and after instrumented proprioceptive rehabilitation relying on sequences of muscle vibration in subacute stroke stages.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • hemiparesis at least transient in lower limb following an acquired brain injury (stroke or traumatic brain injury)

  • French spoken

  • Affiliated to a French social insurance

  • No previous traumatic, vascular or neurodegenerative injuries

  • Having presented during the acute phase or presenting a motor deficit of one of thelower limbs

  • Presenting an absence of autonomy of walking at the entrance of the rehabilitationdepartment

  • In the sub-acute phase, i.e. from 15 days to 6 months after the accident

  • Presenting moderate cognitive disorders allowing them to understand instructions andgive their consent

Exclusion

Exclusion Criteria:

  • strong cognitive disorders

  • maintenance of justice, tutelage, legal guardianship

  • Pregnancy and breastfeeding

  • Outpatients who do not have weekly follow-up in the rehabilitation department

Study Design

Total Participants: 56
Treatment Group(s): 1
Primary Treatment: Vibrations
Phase:
Study Start date:
June 16, 2022
Estimated Completion Date:
November 30, 2026

Study Description

Randomized control trial : 28 patients with active vibrations vs. 28 patients with sham stimulation Subacute phase : D15 to 6 months after stroke or patients with traumatic brain injury with similar semiology as stroke (hemiparesis) Measure at baseline : Electrophysiological investigations (EMG,EEG, MRI, clinical evaluation) Treatment of 5 weeks with 3 sessions of vibrations or sham a week Evaluation at mid time (electrophysiology and clinical examinations) Final examination (electrophysiology, MRI and clinical examination)

Connect with a study center

  • Pitié-Salpêtrière Hospital

    Paris, 75013
    France

    Active - Recruiting

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