Safety and Efficacy of Cannabidiol (CBD) for Symptoms of PTSD in Adults

Inclusion Criteria:

All Subjects:

1. Ability and willingness to provide informed consent

2. Stated willingness to comply with all study procedures and availability for theduration of the study

3. Male or female, aged 21-65

4. Able to read and communicate in English.

5. THC use must be less than 3 days per week

Subjects who consent to driving procedures:

1. Legally licensed and experienced drivers (>3 years driving experience), including acorrected or uncorrected visual acuity of <20/50 OU (to meet state drivingrequirements for vision).

2. Active drivers (≥1hr or 25 miles driving per week). Driving a single car at least 90% of driving time (to permit installation of study driving equipment) and have carinsurance for the vehicle used in the study.

PTSD Subjects

1. Meets DSM-5 diagnostic criteria for a current diagnosis of Post-Traumatic StressDisorder on the MINI, with symptoms present for at least 1 month.

2. Clinician administered CAPS-5 score ≥27 at study induction and start of CBDobservation.

3. Stable psychopharmacologic and/or psychotherapeutic intervention for 4 weeks priorto enrollment.

Exclusion Criteria:

All Subjects:

1. Current use of prescribed or commercially available CBD products, includingEpidiolex®.

2. Suicidal ideation (as defined by answer of "yes" to item 4 or 5 on the baselineColumbia Suicide Severity Rating Scale (C-SSRS) or attempt in the 6 months prior toenrollment.

3. Cognitive impairment in the clinical judgment of the investigator that would impactability to complete study assessments or confound study results (e.g.,neurodegenerative condition or other).

4. Meets criteria for substance or alcohol use disorder of moderate or greater severityin the 6 months prior to study entry based on the MINI. Nicotine dependence ispermitted.

5. Self-reported cannabis use on > 3 days/week starting 4 weeks prior to enrollment.

6. Positive urine drug screen for illicit substances other than cannabis.

7. Pregnant, measured by serum hCG test, or breastfeeding.

8. Co-morbid medical conditions or concomitant treatments that may adversely impactability to participate in the trial in the clinical judgment of the investigator.E.g., significant immunosuppression due to active chemotherapy, recent organtransplant, uncontrolled diabetes, glomerular filtration rate (GFR) < 25ml/min or ondialysis, recent acute myocardial infarction (MI), Class IV heart failure, or takingany high-risk drugs for drug-drug interactions (see Appendix A).

9. Treatment with another investigational drug or other intervention within the 3months prior to enrollment.

10. History of psychosis (schizophrenia, schizophreniform disorder, schizoaffectivedisorder, or substance induced psychosis), active bipolar disorder, or borderlinepersonality disorder diagnosed by a mental health professional.

11. History of open head injury

12. Self-report of exposure to trauma in the 30 days prior to enrollment.

13. Active military service in the 30 days prior to enrollment.

14. Inpatient psychiatric hospitalization within 6 months prior to enrollment.

15. Seizure in the last 6 months.

16. Use of concomitant anti-viral HIV medications (PrEP is permitted).

Control Subjects:

1. No history of diagnosed PTSD.

2. Pregnant, measured by self-report, or breastfeeding

Subjects who consent to fMRI procedures:

1. Claustrophobia, pregnancy, or any condition (e.g., significant hearing difficulties)that would preclude MRI scanning in the clinical judgment of the investigator.

2. Presence of metal objects in or on the body such as pacemakers, aneurysm clips,metallic prostheses, bone plates, braces, orthodontic devices, cochlearimplants/hearing aids, non-removable piercings/implants or metallic-ink tattoos, orshrapnel fragments.

3. Other confounding medical conditions (e.g., Tourette's or Tic Disorder) that wouldpreclude MRI scanning in the clinical judgement of the investigator. PTSD Subjects:

4. Index trauma before age 18 and no other traumatic experiences which couldrelate/identify as part of PTSD.

5. Any history of allergic reaction or significant AEs related to cannabis, CBD, orTHC.

6. Currently involved in events giving rise to the disease. 20. Alanine transaminase (ALT)/Aspartate transaminase (AST)/Bilirubin > 2 x upper limit of normal (ULN) atscreening. Abnormalities on the comprehensive metabolic panel or complete bloodcount which are deemed to be of clinical significance in the judgement of theinvestigator and clinical team will be evaluated in the clinical context of thesubject's history and physical examination to determine eligibility. Testing may berepeated if clinically appropriate at the discretion of the investigator.

7. For subjects of who can become pregnant, refusal to use at least one form of birthcontrol throughout study participation. Forms of birth control may include, but arenot limited to, condoms (male or female) with or without spermicide, diaphragm, orcervical cap with or without spermicide, abstinence, or hormonal or implanted birthcontrol (e.g., pill, injection, intra-uterine device [IUD], implant).