Clinical Efficacy of Exosome in Degenerative Meniscal Injury

Inclusion Criteria:

• Accepting the Informed Consent Form
• Degenerative meniscus damage grade 1, 2 or 3 on MRI in both right and left knees, andalso the patient does not want surgical treatment
• Patients with the same degenerative meniscus grade in both knees
• Patients with ongoing pain
• Patients without a history of malignancy
• Absence of signs of unstable meniscus tear such as snagging or locking
• Patients with stage 0, 1 or 2 gonarthrosis according to Kellgren-Lawrence gonarthrosisstaging
• Patients without lower extremity malalignment

Exclusion Criteria:

• Patients whose treatment method was explained and who did not accept the method
• Patients outside the working-age range
• Congenital lesion
• Patients requiring surgical treatment (e.g. bucket handle tear and locked knee)
• Active inflammatory or connective tissue disease is thought to affect the patient'spain (eg lupus, rheumatoid arthritis, fibromyalgia)
• Local or systemic infection
• Pregnant or breastfeeding women
• Active endocrine disorder that may affect the assessment of patient's pain (eg,hypothyroidism, diabetes)
• Active neurological disorder that may affect the assessment of the patient's pain (eg,peripheral neuropathy, multiple sclerosis)
• Active heart disease
• Presence of a pacemaker
• Conditions where MR-I is contraindicated
• Patients with stage 3 or 4 gonarthrosis according to Kellgren-Lawrence gonarthrosisstaging
• Patients with lower extremity malalignment
• Patients with signs of unstable meniscus tear such as snagging or locking