Improving Spatial Perception and Speech Understanding in Multitalker Mixtures

Last updated: November 16, 2022
Sponsor: Boston University Charles River Campus
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hearing Loss

Deafness

Hearing Impairment

Treatment

N/A

Clinical Study ID

NCT05260307
4218E
R01DC015760
  • Ages 18-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this study is to investigate several approaches for improving spatial perception and speech intelligibility in multitalker listening situations for hearing-aid users. The hypotheses are that spatial perception and speech intelligibility will be improved by (1) increased high-frequency audibility, (2) speech envelope enhancement, and/or (3) appropriate sound image externalization.

Eligibility Criteria

Inclusion

Inclusion Criteria: Normal-Hearing Subjects

  • 18 to 35 years of age

  • Audiometric thresholds that do not exceed 20 dB HL at any frequency from 250 to 8000 Hz

  • Able to provide informed consent and understand experimental instructions

  • Normal or corrected-to-normal vision

Inclusion Criteria: Hearing-Impaired Subjects

  • 18 to 80 years of age

  • Documented sensorineural hearing loss

  • Able to provide informed consent and understand experimental instructions

  • Normal or corrected-to-normal vision

Exclusion Criteria (some experiments)

  • Non-native speakers of English

Study Design

Total Participants: 220
Study Start date:
March 09, 2022
Estimated Completion Date:
November 30, 2026

Study Description

The purpose of this study is to investigate several approaches for improving spatial perception and speech intelligibility in multitalker listening situations for hearing-aid users. Aim 1 will investigate how well different amplification strategies provide access to the spectrotemporally sparse speech information that is available in multitalker mixtures. The hypothesis is that subtle differences in high-frequency audibility across different strategies may have much greater effects on the intelligibility of sparse speech than intact speech. This Aim will involve 40 subjects with hearing loss across 2 experiments. Aim 2 is an exploratory aim that will investigate the potential of a speech enhancement algorithm to improve spatial hearing in multitalker mixtures. The hypothesis is that speech enhancement, in addition to its established monaural benefits, will enhance the salience of interaural time differences and thus provide binaural benefits in multitalker mixtures. This Aim will involve 30 subjects with normal hearing and 60 subjects with hearing loss across 3 experiments. Aim 3 will investigate how different hearing-aid styles affect sound externalization. The hypothesis is that hearing aids can disrupt sound externalization, which in turn impacts speech intelligibility in multitalker mixtures. This Aim will involve 30 subjects with normal hearing and 60 subjects with hearing loss across 3 experiments.

This is a prospective design involving adult human subjects. While the investigators will recruit subjects with normal and impaired hearing, all subjects will be assigned to the same set of experimental conditions. Therefore, for the purposes of intervention (or prospective assignment), the subjects can be treated as a single group completing the same intervention (or set of interventions). The behavioral experiments involve listening to speech sounds (either unaided, with hearing aids, or with simulated hearing aids), and providing responses related to spatial perception or speech intelligibility. The order of experimental conditions will be randomized for each subject in order to control for order effects. All of the experimental tasks and outcome measures have been previously established, have good reliability and validity, and will be appropriate for informing future studies.

Connect with a study center

  • Boston University

    Boston, Massachusetts 02215
    United States

    Active - Recruiting

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