The Vallania Study: A Case Control Study for the Development of Multiomics Blood Tests for Cancer Screening

Key Inclusion Criteria:

• Age at least 30 years

• Able and willing to provide blood samples per protocol

• Able to comprehend and willing to sign and date the informed consent documents

• Participants must meet one of the following:

• Diagnosed with a single primary cancer that has not yet been treated

• No evidence or treatment of any cancer for at least 5 years prior to enrollment

Key Exclusion Criteria:

• A medical condition which, in the opinion of the investigator, should precludeenrollment in the study

• Known to be pregnant

• Any therapy for cancer, including surgery, chemotherapy, immunotherapy, and/orradiation therapy in the 5 years preceding enrollment

• Participated or currently participating in a clinical research study in which anexperimental medication has been administered in the last 30 days

• Participated in or currently participating in another Freenome clinical study

• For the control cohort: Any previous cancer diagnosis in the 5 years precedingenrollment, or recurrence of the same primary cancer within any timeframe; orconcurrent diagnosis of multiple primary cancers within any timeframe

• For the cancer cohorts: Any previous cancer diagnosis in the 5 years precedingenrollment, apart from the current cancer diagnosis; OR recurrence of the sameprimary cancer within any timeframe; OR concurrent diagnosis of multiple primarycancers within any timeframe