Phase 2 to Assess Efficacy and Safety in AR882 Alone or in Combination With Allopurinol in Patients With Tophaceous Gout

Inclusion Criteria:

• History of gout

• at least 1 measurable tophus on the hands/wrists and/or feet/ankles ≥ 5 mm and ≤ 30mm in the longest diameter.

• Patients who are NOT on approved ULT must have sUA > 7 mg/dL

• Patients who are on medically appropriate ULT must have sUA > 6 mg/dL

• Estimated Glomerular Filtration Rate (eGFR) ≥ 45 mL/min/1.73m2

Exclusion Criteria:

• Malignancy within 5 years, except for successfully treated basal or squamous cellcarcinoma of the skin

• Pregnant or breastfeeding

• History of kidney stones