Precise Procedural and PCI Plan (P4)

Inclusion Criteria:

1. The subject must be at least 18 years of age and younger than 80 years old.

2. Subject must have evidence of myocardial ischemia (e.g., stable angina, silentischemia (ischemia in the absence of chest pain or other anginal equivalents),unstable angina, or acute myocardial infarction) suitable for elective PCI.

3. Patients with a clinical indication for revascularization presenting with stablecoronary artery disease or stabilized acute coronary syndrome defined as followsunstable angina (Braunwald class IB, IC, IIB, IIC, IIIB, IIIC), patients with NSTEMIwithout high-risk features such as recurrence of chest pain, ST-segmentdepression>1mm in ≥6 leads plus ST-segment elevation in aVR, life-threateningarrhythmias, mechanical complications of MI, resuscitated cardiac arrest, GRACE riskscore>140.

4. All target lesions must be planned for treatment only in vessels with RVD ≥2.5 mmand ≤4.0 mm.

5. No more than 2 target vessels are allowed. A bifurcation counts as a single lesioneven if the side branch is planned to be treated.

6. Subject must provide written Informed Consent before any study-related procedure.

Exclusion Criteria:

1. Age <18 years or ≥80 years old

2. STEMI as clinical presentation.

3. Uncontrolled or recurrent ventricular tachycardia.

4. Hemodynamic instability.

5. Severe renal dysfunction, defined as an eGFR ≤30 mL/min/1.73 m2.

6. Atrial fibrillation, flutter, or arrhythmias.

7. Previous PCI or CABG.

8. The target lesion is in the left main coronary artery

9. BMI ≥35 kg/m2.

10. Insufficient CT quality assessed by the Core lab.

11. Comorbidity with life expectancy ≤ 2 years.

12. Inability to take DAPT (both aspirin and a P2Y12 inhibitor) for at least 12 monthsin the patient presenting with an ACS, or at least 6 months in the patientpresenting with stable CAD, unless the patient is also taking chronic oralanticoagulation in which case a shorter duration of DAPT may be prescribed per localstandard of care.

13. Planned major cardiac or non-cardiac surgery within 24 months after the indexprocedure Note: Major surgery is any invasive operative procedure in which anextensive resection is performed, e.g., a body cavity is entered, organs areremoved, or normal anatomy is altered. Note: Minor surgery is an operation on thesuperficial structures of the body or a manipulative procedure that does not involvea serious risk. Planned minor surgery is not excluded.

14. Prior PCI within the target vessel within 12 months.

15. Subject has known hypersensitivity or contraindication to any of the study drugs (including all P2Y12 inhibitors, one or more components of the study devices,including everolimus, zotarolimus, biolimus, sirolimus, cobalt, chromium, nickel,platinum, tungsten, acrylic, and fluoropolymers, or radiocontrast dye that cannot beadequately pre-medicated.

16. The subject has received a solid organ transplant that is functioning or is activeon a waiting list for any solid organ transplants with expected transplantationwithin 24 months.

17. The subject receives immunosuppressant therapy or has known immunosuppressive orsevere autoimmune disease that requires chronic immunosuppressive therapy (e.g.,human immunodeficiency virus, systemic lupus erythematosus, etc.). Note:corticosteroids are not included as immunosuppressant therapy.

18. The subject has previously received or is scheduled to receive radiotherapy to acoronary artery (vascular brachytherapy) or the chest/mediastinum.

19. Subject has a platelet count <100,000 cells/mm3 or >700,000 cells/mm3.

20. The subject has a documented or suspected hepatic disorder as defined as cirrhosisor Child-Pugh ≥ Class B.

21. The subject has a history of bleeding diathesis or coagulopathy or has had asignificant gastro-intestinal or significant urinary bleed within the past sixmonths. The subject has had a cerebrovascular accident or transient ischemicneurological attack (TIA) within the past six months, or any prior intracranialbleed, or any permanent neurologic defect, or any known intracranial pathology (e.g., aneurysm, arteriovenous malformation, etc. The subject has a life expectancy <2 years for any non-cardiac cause.

22. Subject is currently participating in another investigational drug or deviceclinical study.

23. Pregnant or nursing subjects and those who plan pregnancy in the period up to 2years following index procedure. Female subjects of child-bearing potential musthave a negative pregnancy test done within 7 days prior to the index procedure persite standard test.

24. Presence of other anatomic or comorbid conditions, or other medical, social, orpsychological conditions that, in the investigator's opinion, could limit thesubject's ability to participate in the clinical investigation or to comply withfollow-up requirements, or impact the scientific soundness of the clinicalinvestigation results.

25. Unable to provide written informed consent (IC).