Prodromal Parkinsonian Features in GBA1 Mutation Carriers

Last updated: November 22, 2023
Sponsor: Shaare Zedek Medical Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

Gaucher Disease

Treatment

The investigators aim to identify prodromal PD in a cohort of carriers of Gaucher disease.

Clinical Study ID

NCT05253560
SZMC-0168-17
  • Ages 40-75
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Objective of the trial. To define a sub-population which is at increased risk of developing Parkinson, beyond the fact of carrying Gaucher; in this sub-population the investigators shall conduct a comprehensive evaluation that includes a variety of non-invasive tests, whose purpose is to evaluate the state of the pre- Parkinson's disease signs, signs which can appear, even twenty years before the appearance of the disease, and also to compare them to a group of diagnosed Gaucher patients and a group of healthy people who are not carriers of Gaucher disease.

A group of those carriers will be available for trial or for treatment, if there will be a medicine for the prevention of the development of Parkinson, obtainable.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Willing to participate

Exclusion

Exclusion Criteria:

  • PD patients
  • Dementia

Study Design

Total Participants: 600
Treatment Group(s): 1
Primary Treatment: The investigators aim to identify prodromal PD in a cohort of carriers of Gaucher disease.
Phase:
Study Start date:
May 16, 2017
Estimated Completion Date:
December 31, 2025

Study Description

The carriers, the healthy people and the Gaucher patients will undergo a number of non-invasive tests, which test the pre-Parkinson signs.

The tests are based on various sense tests, blood tests, measuring of blood pressure, lying and standing, ultra-sound of the brain and a neurological test (test of the nervous system and various questionnaires).

Connect with a study center

  • Michal Becker- Cohen

    Jerusalem, Please Select... 9103102
    Israel

    Active - Recruiting

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