Transcranial Alternating Current Stimulation Combined With 40Hz Sound Stimulation for Treatment Alzheimer's Disease

Inclusion Criteria:

1. Age 40-80 years, male or female;
2. Meet the diagnosis AD formulated by the National Institute on Aging and theAlzheimer's Association (NIA-AA) dementia diagnostic criteria;
3. Clinical Dementia Rating Scale (CDR) =1.0 or 2.0;
4. MMSE score ≤ 24;
5. Able to move freely or with the aid of a walker or crutches;
6. Good vision and hearing, able to cooperate with examination and treatment;
7. Subjects voluntarily joined and had a guardian to sign the informed consent.

Exclusion Criteria:

1. The presence of preoperative structural brain abnormalities (such as tumors, cerebralinfarction, hydrocephalus or intracranial hemorrhage);
2. The presence of other neurological disorders such as multiple sclerosis, epilepsy,Parkinson's disease, etc;
3. Psychiatric system disorders: such as anxiety disorders, affective disorders such asdepression, or pharmacogenic psychiatric disorders;
4. Severe medical illness, current use of respiratory medications, cardiovascularmedications, anticonvulsants or psychoactive drugs and clinically significantgastrointestinal, renal, hepatic, respiratory, infectious, endocrine or cardiovasculardisease, cancer, alcoholism or drug addiction;
5. Severe hearing and visual impairment;
6. Patients with clinical comorbidities with a life expectancy of less than 2 years;
7. Patients who have undergone cranial surgery;
8. Contraindications to undergoing magnetic resonance imaging or receiving transcranialalternating current stimulation (pacemakers, post DBS surgery);
9. Eczema or sensitive skin;
10. Familial Alzheimer's disease;
11. Presence of other types of dementia: vascular dementia, Lewy body dementia,frontotemporal dementia, infectious dementia, etc;
12. Other conditions that, in the opinion of the investigator, may not be suitable forthis study.