COLchicine On-admission to Reduce Inflammation in Acute Coronary Syndrome (COLOR-ACS)

Inclusion Criteria:

• non-ST elevation acute coronary syndrome;

• ≥ 18 years;

• statin-naive.

Exclusion Criteria:

• prior statin therapy and/or colchicine treatment;

• known allergy or hypersensitivity to colchicine or statins;

• current treatment with potent inhibitors of CYP3A4 or P-glycoprotein (eg.,Cyclosporin, antiretroviral drugs, antimycotics, erythromicin and clarythromycin);

• previous or scheduled administration of any immunosuppressive therapy;

• known active malignancy;

• severe kidney disease (creatinine > 3 mg/dl or dialysis)

• severe liver disease (ALT and/or AST, > double ref. normal values in case of (a)total bilirubin > double ref. normal values, or (b) alteration in coagulation (INR> 1,5);

• severe heart failure (NYHA class ≥ 3 or cardiogenic shock) at hospital presentation;

• severe acute or chronic gastro-intestinal disease (nausea, vomiting, diarrhea,malabsorption disease, malnutrition);

• pregnancy or lactation;

• current COVID-19 or other infectious disease;

• refusal of consent.