Informed Choice - Compass

Inclusion Criteria:

1. Participant is 45 to 70 years of age, inclusive.

2. Participant presents for a primary care appointment.

3. Participant understands the study procedures and can provide informed consent toparticipate in the study and authorization for release of relevant protected healthinformation (PHI) to the study Investigator.

4. Participant has never been screened for CRC.

Exclusion Criteria:

1. Participant has symptoms or signs that require immediate, or near-term referral fordiagnostic or therapeutic colonoscopy.

2. Participant is due for CRC screening within three months and is already scheduledfor colonoscopy.

3. Participant has a personal history of CRC or colonic adenomatous or sessile serratedpolyps.

4. Participant has a personal history of inflammatory bowel disease.

5. Participant has a family history of CRC in at least one first- or second-degreerelative diagnosed prior to age 60 and/or at least 2 first-degree relativesdiagnosed with CRC at any age.

6. Participant has a personal diagnosis or family history of any of the followingconditions:

7. Familial adenomatous polyposis (also referred to as "FAP", including attenuatedFAP and Gardner's syndrome),

8. Hereditary non-polyposis CRC syndrome (also referred to as "HNPCC" or "LynchSyndrome"),

9. Other hereditary cancer syndromes including, but are not limited toPeutz-Jeghers Syndrome, MYH-Associated Polyposis (MAP), Turcot's (or Crail's)Syndrome, Cowden's Syndrome, Juvenile Polyposis, Neurofibromatosis, or FamilialHyperplastic Polyposis.

10. Participant has a diagnosis of Cronkhite-Canada Syndrome.

11. Participant is current with CRC screening, including gFOBT or FIT within thepreceding 12 months, Cologuard within the preceding 3 years, flexible sigmoidoscopyor CT colonography within the preceding 5 years, or colonoscopy within the preceding 10 years. Participants can be enrolled up to 3 months prior to screening due date.

12. Participant has any condition that in the opinion of the Investigators shouldpreclude participation in the study, including comorbid illnesses precludingendoscopic evaluation or that limit life expectancy to less than 10 years.