Renal Artery DenervatIon Using Radial accesS in Uncontrolled HyperTensioN

Inclusion Criteria:

1. Patient ≥18 and ≤75 years old

2. Persistent uncontrolled hypertension defined as the mean of three consecutivemeasurements of systolic office blood pressure >150 mmHg and diastolic office bloodpressure >80 mmHg as well as ambulatory daytime systolic blood pressure ≥140 mmHgdespite prescription of 2 to 5 anti-hypertensive drugs including anangiotensin-receptor blocker or an angiotensin-converting enzyme inhibitor incombination with a diuretic or calcium channel blocker

3. Renal artery diameter ≥3 mm and ≤8 mm (to be assessed during the procedure)

4. Patient can be treated according to the instructions for use (IFU)

5. Patient eligible for TransFemoral Access and TransRadial Access

6. Patient, who understands the trial requirements and the treatment procedures andprovides written informed consent

Exclusion Criteria:

1. Estimated glomerular filtration rate (eGFR) <45 mL/min/m² (MDRD formula)

2. Prior renal transplant

3. Presence of accessory artery (polar artery) supplying more than 20% of renalparenchyma that cannot be treated (renal artery diameter <3 mm) with renaldenervation

4. Patient lacking capacity (i.e. patient suffering from dementia and others) toprovide informed consent

5. Patient currently participating in another investigational drug or device study

6. Pregnant or breastfeeding women or those intending to become pregnant before the endof the follow-up

7. Subjects under judicial protection, guardianship or curatorship or subjects deprivedof their liberty by judicial or administrative decision