Does a Multi-ingredient Pre-workout Supplement Enhance Cycling Time Trial Performance?

Last updated: July 28, 2025
Sponsor: University of Exeter
Overall Status: Completed

Phase

N/A

Condition

Healthy Volunteers

Treatment

Placebo

Ladder Supplement

Clinical Study ID

NCT05230862
2021-M-38
  • Ages 18-40
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The aim of the present study is to test the effect of ingesting a multi-ingredient pre- exercise supplement containing caffeine, creatine, beta-alanine and L-Citrulline compared to a placebo, on endurance exercise performance.

Eligibility Criteria

Inclusion

Exclusion criteria:

  • Any diagnosed metabolic health condition

  • Pregnant

  • Non-habitual caffeine intake

  • Smoker

  • No endurance training

  • Diagnosed Cardiovascular disease

  • Recent history of musculoskeletal injury

  • Anti-depressant and anti-anxiety medication

Inclusion criteria

  • Age 18-40

  • Healthy

  • Highly trained endurance athletes (V̇O2max: males >55 and females >50 mL⋅kg bm-1⋅min-1)

  • Both males and females are allowed to participate. If females are on the oral contraceptive pill they are to be tested on consecutive weeks. If they are not on the oral contraceptive pill, then female subjects are to be tested every 4 weeks, at the same point of their menstrual cycle.

Study Design

Total Participants: 12
Treatment Group(s): 2
Primary Treatment: Placebo
Phase:
Study Start date:
December 02, 2021
Estimated Completion Date:
September 30, 2022

Connect with a study center

  • School of Sport and Health Sciences

    Exeter, EX4
    United Kingdom

    Site Not Available

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