The PURI-HF (Air Purifiers on Heart Failure) Trial

Last updated: March 24, 2025
Sponsor: NYU Langone Health
Overall Status: Active - Recruiting

Phase

N/A

Condition

Congestive Heart Failure

Chest Pain

Hyponatremia

Treatment

AirOk Air Purifier

Placebo Air Filter

Clinical Study ID

NCT05230784
21-00954
R01ES033222
  • Ages > 18
  • All Genders

Study Summary

Indoor air pollution and fine mode particulate matter with an aerodynamic diameter smaller than 2.5 micrometers (PM2.5) is a major contributor to global morbidity and mortality, particularly due to cardiovascular disease. This project aims to demonstrate the efficacy, feasibility and effectiveness of portable air filters in improving indoor PM2.5 levels and improving functional capacity of heart failure patients with reduced ejection fraction in India. The findings from the project will add to existing knowledge of innovative and scalable strategies to improve environmental and cardiovascular health worldwide.

The overall objective of this study is to demonstrate the efficacy, feasibility, and effectiveness of portable air filters in improving indoor PM2.5 levels and improving functional capacity of heart failure patients with reduced ejection fraction in India.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adults ≥ 18 years of age diagnosed with HF with a reduced ejection fraction of ≤ 40%within the last six months in NYHA class II-IV.

Exclusion

Exclusion Criteria:

  • listed for a cardiac transplant

  • history of CRT device implantation in last 3 months

  • on oxygen therapy

  • with severe pulmonary disease

  • participants unable to ambulate

Study Design

Total Participants: 600
Treatment Group(s): 2
Primary Treatment: AirOk Air Purifier
Phase:
Study Start date:
March 06, 2024
Estimated Completion Date:
April 30, 2026

Connect with a study center

  • Centre for Chronic Disease Control (CCDC)

    Thiruvananthapuram, Kerala
    India

    Active - Recruiting

  • All India Institute of Medical Sciences (AIIMS)

    Delhi, Punjab
    India

    Active - Recruiting

  • Public Health Foundation of India (PHFI)

    Ludhiāna, Punjab
    India

    Active - Recruiting

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